THE EFFECTS OF MATERNAL DIABETES ON BRAIN LATERAL VENTRICLES IN NEWBORN RATS

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TEHRANIPOUR M.; KHAYATZADEH J.; GHORBANI Z.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2010 | Volume:12 | Issue:4 (49) Page(s): 36-43

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Title

THE EFFECTS OF MATERNAL DIABETES ON BRAIN LATERAL VENTRICLES IN NEWBORN RATS

Author(s)

TEHRANIPOUR M. | KHAYATZADEH J. | GHORBANI Z. | Issue Writer Certificate

Keywords

HYDROCEPHALYQ3

GESTATIONAL DIABETES MELLITUSQ3

LATERAL VENTRICLESQ3

Abstract

Background: Maternal diabetes is associated with an increased risk of several complications in the offspring, such as the growth of congenital disturbances and malformations. In the present study, we examined the effects of maternal hyperglycemia on the volume of brain and lateral ventricle in newborn Wistar rats. Materials and Methods: In this experimental study, on the 7th day of pregnancy, hyperglycemia was induced by a single injection (i.p.) of streptozotocin (55 mg kg-1) and the animals in control group were given an equal volume of citrate buffer. After parturition on the first day of birth, a litter was randomly selected from each mother, their brains dissected and fixed in 10% formalin. Then they were sectioned with 7mm thickness and stained by H.E. Through the use of stereological techniques and systematic random sampling scheme, the volume of the brain and LATERAL VENTRICLES were estimated.Results: Statistical analyses showed significant increases (p<0.05) in the volume of the brains and LATERAL VENTRICLES in the experiment group in comparison to the control group.Conclusion: By affecting blood brain barrier permeability in newborn rats, maternal diabetes can generate a large amount of CSF. These effects can bring about brain disorders such as hydrocephalus.

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APA: Copy

TEHRANIPOUR, M., KHAYATZADEH, J., & GHORBANI, Z.. (2010). THE EFFECTS OF MATERNAL DIABETES ON BRAIN LATERAL VENTRICLES IN NEWBORN RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 12(4 (49)), 36-43. SID. https://sid.ir/paper/69612/en

Vancouver: Copy

TEHRANIPOUR M., KHAYATZADEH J., GHORBANI Z.. THE EFFECTS OF MATERNAL DIABETES ON BRAIN LATERAL VENTRICLES IN NEWBORN RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2010;12(4 (49)):36-43. Available from: https://sid.ir/paper/69612/en

IEEE: Copy

M. TEHRANIPOUR, J. KHAYATZADEH, and Z. GHORBANI, “THE EFFECTS OF MATERNAL DIABETES ON BRAIN LATERAL VENTRICLES IN NEWBORN RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 12, no. 4 (49), pp. 36–43, 2010, [Online]. Available: https://sid.ir/paper/69612/en

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