Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazoleinduced seizures in rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARAMI REZA; HOSSEINI MAHMOUD; MOHAMMADPOUR TOKTAM; GHORBANI AHMAD; SADEGHNIA HAMID REZA; RAKHSHANDEH HASSAN; VAFAEE FARZANEH; ESMAEILIZADEH MAHDI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Current Journal of Neurology Year:2015 | Volume:14 | Issue:2 Page(s): 59-66

Download Full-Text

View:

283

Download:

Cites:

Information Journal Paper

Title

Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazoleinduced seizures in rats

Author(s)

Keywords

Coriandrum sativum

Pentylenetetrazole

Seizures

Rat

Oxidative Stress

Brain

Abstract

Background: An important role for Oxidative Stress, as a consequence of epileptic Seizures, has been suggested. Coriandrum sativum has been shown that have antioxidant effects. Central nervous system depressant effects of C. sativum have also been reported. In this study, the effects of hydroalcoholic extract of aerial parts of the plants on Brain tissues oxidative damages following Seizures induced by Pentylenetetrazole (PTZ) was investigated in Rats. Methods: The Rats were divided into five groups and treated: (1) Control (saline), (2) PTZ (90 mg/kg, i. p. ), (3-5) three doses (100, 500 and 1000 mg/kg of C. sativum extract (CSE) before PTZ. Latencies to the first minimal clonic Seizures (MCS) and the first generalized tonic-clonic Seizures (GTCS) were recorded. The cortical and hippocampal tissues were then removed for biochemical measurements. Results: The extract significantly increased the MCS and GTCS latencies (P < 0. 01, P < 0. 001) following PTZ-induced Seizures. The malondialdehyde (MDA) levels in both cortical and hippocampal tissues of PTZ group were significantly higher than those of the control animals (P < 0. 001). Pretreatment with the extract prevented elevation of the MDA levels (P < 0. 010– P < 0. 001). Following PTZ administRation, a significant reduction in total thiol groups was observed in both cortical and hippocampal tissues (P < 0. 050). Pretreatment with the 500 mg/kg of the extract caused a significant prevention of decreased in total thiol concentRation in the cortical tissues (P < 0. 010). Conclusion: The present study showed that the hydroalcoholic extract of the aerial parts of C. sativum possess significant antioxidant and anticonvulsant activities.

Cites

EFFECT OF LONG-TERM ADMINISTRATION OF FERULA GUMMOSA ROOT EXTRACT ON SERUM OXIDANT-ANTIOXIDANT STATUS

References

No record.

Cite

APA: Copy

KARAMI, REZA, HOSSEINI, MAHMOUD, MOHAMMADPOUR, TOKTAM, GHORBANI, AHMAD, SADEGHNIA, HAMID REZA, RAKHSHANDEH, HASSAN, VAFAEE, FARZANEH, & ESMAEILIZADEH, MAHDI. (2015). Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazoleinduced seizures in rats. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 14(2), 59-66. SID. https://sid.ir/paper/696143/en

Vancouver: Copy

KARAMI REZA, HOSSEINI MAHMOUD, MOHAMMADPOUR TOKTAM, GHORBANI AHMAD, SADEGHNIA HAMID REZA, RAKHSHANDEH HASSAN, VAFAEE FARZANEH, ESMAEILIZADEH MAHDI. Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazoleinduced seizures in rats. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2015;14(2):59-66. Available from: https://sid.ir/paper/696143/en

IEEE: Copy

REZA KARAMI, MAHMOUD HOSSEINI, TOKTAM MOHAMMADPOUR, AHMAD GHORBANI, HAMID REZA SADEGHNIA, HASSAN RAKHSHANDEH, FARZANEH VAFAEE, and MAHDI ESMAEILIZADEH, “Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazoleinduced seizures in rats,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 14, no. 2, pp. 59–66, 2015, [Online]. Available: https://sid.ir/paper/696143/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops