EXERCISE-INDUCED OXIDATIVE SHIFT OF LACTATE DEHYDROGENASE ISOFORMS IN CEREBROSPINAL FLUID OF MALE WISTAR RATS

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SHEIKHHOSSEINI NASRIN; Nikooie Rohollah; AMINAEI MOHSEN

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2018 | Volume:21 | Issue:1 (130) Page(s): 52-62

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Title

EXERCISE-INDUCED OXIDATIVE SHIFT OF LACTATE DEHYDROGENASE ISOFORMS IN CEREBROSPINAL FLUID OF MALE WISTAR RATS

Author(s)

SHEIKHHOSSEINI NASRIN | Nikooie Rohollah | AMINAEI MOHSEN | Issue Writer Certificate

Keywords

ENDURANCE TRAININGQ1

LACTATE DEHYDROGENASEQ1

LACTATE METABOLISMQ1

Abstract

Background: The aim of the present study was to investigate the effect of ENDURANCE TRAINING on the content of LACTATE DEHYDROGENASE isoforms (LDHA and LDHB) and isozymes in cerebrospinal fluid of male wistar rats.Materials and Methods: Seventeen animals (5 weeks old) were randomly divided into two groups according their body weight: control (C; n=9) and trained (T; n=8). The animals from the T group were underwent a training program for 12 weeks (started at 20 m/min for 30 min and finished at 26 m/min for 60 min at the last week). Cerebrospinal fluid (CSF) samples were collected from cisterna Magna 72 hours after the last exercise session. LDH Isoforms and isozymes were measured by ELISA and Electrophoresis techniques, and the comparisons between groups were evaluated by student t-test.Results: Both LDHA and LDHB isoforms were found in the CSF of the C group; LDH1 and LDH5 had the highest and lowest content, respectively. Following the twelve-week training protocol, LDHB (p<0.01), LDH1 (p<0.01), and LDH2 concentrations (p<0.01) were significantly increased in the T group compared with those from the C group and LDH3 concentrations (p<0.01) and LDHA/LDHB ratio (p<0.01) were significantly decreased. ENDURANCE TRAINING had no effect on LDHA and LDH4.Conclusion: ENDURANCE TRAINING is associated with oxidative shift of LACTATE DEHYDROGENASE isoforms and isozymes in cerebrospinal fluid which could be considered as a prelude to aerobic metabolism of lactate in the brain.

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APA: Copy

SHEIKHHOSSEINI, NASRIN, Nikooie, Rohollah, & AMINAEI, MOHSEN. (2018). EXERCISE-INDUCED OXIDATIVE SHIFT OF LACTATE DEHYDROGENASE ISOFORMS IN CEREBROSPINAL FLUID OF MALE WISTAR RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(1 (130) ), 52-62. SID. https://sid.ir/paper/69703/en

Vancouver: Copy

SHEIKHHOSSEINI NASRIN, Nikooie Rohollah, AMINAEI MOHSEN. EXERCISE-INDUCED OXIDATIVE SHIFT OF LACTATE DEHYDROGENASE ISOFORMS IN CEREBROSPINAL FLUID OF MALE WISTAR RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;21(1 (130) ):52-62. Available from: https://sid.ir/paper/69703/en

IEEE: Copy

NASRIN SHEIKHHOSSEINI, Rohollah Nikooie, and MOHSEN AMINAEI, “EXERCISE-INDUCED OXIDATIVE SHIFT OF LACTATE DEHYDROGENASE ISOFORMS IN CEREBROSPINAL FLUID OF MALE WISTAR RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 1 (130) , pp. 52–62, 2018, [Online]. Available: https://sid.ir/paper/69703/en

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