THE EFFECT OF HYDROALCOHOLIC EXTRACT OF TRUFFLE ON ESTROGEN AND PROGESTERONE LEVELS IN EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS (MS) IN FEMALE RATS

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ZABIHI ESLAM; MOTAVALLIBASHI SEYED EGHBAL; BAMDAD KHAYAM; PILEVARIBADI FAEGHEH; SHEIKHKANLOUI MILAN HAMID

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Journal: Journal of Arak University Medical Sciences Year:2017 | Volume:20 | Issue:3 (120) Page(s): 48-56

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF TRUFFLE ON ESTROGEN AND PROGESTERONE LEVELS IN EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS (MS) IN FEMALE RATS

Author(s)

Keywords

ESTROGENQ1

MULTIPLE SCLEROSISQ1

PROGESTERONEQ1

RATQ2

TRUFFLEQ2

Abstract

Background: The MULTIPLE SCLEROSIS is a chronic disease of the central nervous system.Since the level of sex hormone and MULTIPLE SCLEROSIS (MS) disease affects one another, the aim of this study was to evaluate the impact of the hydroalcoholic extract of TRUFFLE on the hormone levels of ESTROGEN and PROGESTERONE administered in experimental model of MSinduced RATs.Materials and Methods: In this experimental study, 42 Wistar female RATs, weighing 180±10 grams selected into 6 groups each consisting of 7 RATs. Normal control didn’t receive any treatment and experimental group was given Cuprizone toxin (as a MS model inducer) for 40 days. The experimental groups (2, 3, 4 and 5) in addition to Cuprizone received the normal saline, 110, 220 and 330 mg/kg/0.2ml (i.p.) of Hydroalcoholic extract of TRUFFLE for 12 days too. Blood samples were taken at the end of the twelfth day from all groups involved and levels of sex hormones were measured.Results: Cuprizone decreases ESTROGEN, PROGESTERONE levels and also causes weight loss, while injection of hydroalcoholic extract of TRUFFLE increased serum levels of ESTROGEN (in experimental group 4) and PROGESTERONE (in experimental group 4 & 5) compared to MSinduced group.Conclusion: Results of the study revealed that the hydroalcoholic extract of TRUFFLE (at dosages of 220 and 330 mg/kg) could increase ESTROGEN and PROGESTERONE levels in RATs experienced experimental MULTIPLE SCLEROSIS.

Cites

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF TERFEZIA BOUDIERI ON SPERM PARAMETERS AND TESTOSTERONE LEVELS IN RATS

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APA: Copy

ZABIHI, ESLAM, MOTAVALLIBASHI, SEYED EGHBAL, BAMDAD, KHAYAM, PILEVARIBADI, FAEGHEH, & SHEIKHKANLOUI MILAN, HAMID. (2017). THE EFFECT OF HYDROALCOHOLIC EXTRACT OF TRUFFLE ON ESTROGEN AND PROGESTERONE LEVELS IN EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS (MS) IN FEMALE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(3 (120)), 48-56. SID. https://sid.ir/paper/69789/en

Vancouver: Copy

ZABIHI ESLAM, MOTAVALLIBASHI SEYED EGHBAL, BAMDAD KHAYAM, PILEVARIBADI FAEGHEH, SHEIKHKANLOUI MILAN HAMID. THE EFFECT OF HYDROALCOHOLIC EXTRACT OF TRUFFLE ON ESTROGEN AND PROGESTERONE LEVELS IN EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS (MS) IN FEMALE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(3 (120)):48-56. Available from: https://sid.ir/paper/69789/en

IEEE: Copy

ESLAM ZABIHI, SEYED EGHBAL MOTAVALLIBASHI, KHAYAM BAMDAD, FAEGHEH PILEVARIBADI, and HAMID SHEIKHKANLOUI MILAN, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OF TRUFFLE ON ESTROGEN AND PROGESTERONE LEVELS IN EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS (MS) IN FEMALE RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 3 (120), pp. 48–56, 2017, [Online]. Available: https://sid.ir/paper/69789/en

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