EXAMINING THE EFFECT OF INHIBITION OF LYSYL OXIDASE ON INVOLVED GENES IN HYPERTROPHY FOLLOWING ONE PERIOD OF RESISTANCE TRAINING IN WISTAR RATS

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RAHIMI SADEGH MOEIN; rashidlamir Amin; Haddad Mashhadrizeh Aliakbar; SOUKHTANLOO MOHAMMAD

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2018 | Volume:20 | Issue:12 (129) Page(s): 35-43

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Title

EXAMINING THE EFFECT OF INHIBITION OF LYSYL OXIDASE ON INVOLVED GENES IN HYPERTROPHY FOLLOWING ONE PERIOD OF RESISTANCE TRAINING IN WISTAR RATS

Author(s)

RAHIMI SADEGH MOEIN | rashidlamir Amin | Haddad Mashhadrizeh Aliakbar | SOUKHTANLOO MOHAMMAD | Issue Writer Certificate

Keywords

HYPERTROPHYQ1

LYSYL OXIDASEQ1

RESISTANCE EXERCISEQ2

SKELETAL MUSCLE β-AMINOPROPIONITRILEQ1

Abstract

Background: Recent Research has pointed to the involvement of LYSYL OXIDASE (LOX) in the muscle development. Despite the fact, there is currently no direct evidence that lox is involved in the myogenic factors and exercise-induced HYPERTROPHY. Therefore, the purpose of this study was to investigate the effect of LYSYL OXIDASE inhibition on exercise-induced HYPERTROPHY, as well as the gene expression of MyoD1, myogenin, TGF-b and LOX in FHL muscle of wistar rats.Materials and Methods: In this experimental research, 32 male Wister rats with an average weight of 220±15 were divided into four groups: resistance training, normal control, treated control and treated resistance training. Rats performed a resistance training for 8 weeks in which animals climbed a vertical ladder of 1m and inclined at 85° with weights attached to their tails. In order to inhibit LYSYL OXIDASE, treatment group rats received daily injection of intraperitoneal b-aminopropionitrile (120 mg/kg/day). FHL muscle was extracted to measure relative muscle weight, as well as genes expression of MyoD1, myogenin, TGF-b and LOX by real time-PCR.Results: Relative weight of FHL muscle was decreased significantly in the treated groups with BAPN, compared with normal groups (p<0.05). LYSYL OXIDASE showed a significant increase compared to the normal control group following a resistance training (p<0.05). LOX gene expression in treatment groups showed a significant increase compared to normal control group (p<0.05). TGF-b gene expression in BAPN-treated groups significantly was increased (p<0.05) and Myogenin in treatment groups showed a significant decrease compared to normal control groups (p<0.05). The expression of MyoD1 gene in treatment groups was only decreased significantly in the treated control groups compared to normal control groups (p<0.05).Conclusion: Results showed that inhibiting the lysine oxidase enzyme could affect the genes involved in HYPERTROPHY and reduce the HYPERTROPHY induced by resistance training.

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APA: Copy

RAHIMI SADEGH, MOEIN, rashidlamir, Amin, Haddad Mashhadrizeh, Aliakbar, & SOUKHTANLOO, MOHAMMAD. (2018). EXAMINING THE EFFECT OF INHIBITION OF LYSYL OXIDASE ON INVOLVED GENES IN HYPERTROPHY FOLLOWING ONE PERIOD OF RESISTANCE TRAINING IN WISTAR RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(12 (129) ), 35-43. SID. https://sid.ir/paper/69791/en

Vancouver: Copy

RAHIMI SADEGH MOEIN, rashidlamir Amin, Haddad Mashhadrizeh Aliakbar, SOUKHTANLOO MOHAMMAD. EXAMINING THE EFFECT OF INHIBITION OF LYSYL OXIDASE ON INVOLVED GENES IN HYPERTROPHY FOLLOWING ONE PERIOD OF RESISTANCE TRAINING IN WISTAR RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;20(12 (129) ):35-43. Available from: https://sid.ir/paper/69791/en

IEEE: Copy

MOEIN RAHIMI SADEGH, Amin rashidlamir, Aliakbar Haddad Mashhadrizeh, and MOHAMMAD SOUKHTANLOO, “EXAMINING THE EFFECT OF INHIBITION OF LYSYL OXIDASE ON INVOLVED GENES IN HYPERTROPHY FOLLOWING ONE PERIOD OF RESISTANCE TRAINING IN WISTAR RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 12 (129) , pp. 35–43, 2018, [Online]. Available: https://sid.ir/paper/69791/en

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