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Information Journal Paper

Title

Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β 1 Gene Expressions in Alcoholic Rats

Pages

  33-40

Abstract

 Background and Objectives: Curcumin and Exercise training are suggested to improve hepatic disorders. The aim of this study was to investigate effects of two weeks of swimming training and Curcumin supplementation on platelet-derived growth factor (PDGF-BB) and transforming growth factor beta 1 (TGF-β 1) gene expressions following Ethanol consumption in Wistar male rats. Materials and Methods: Totally, 32 Wistar male rats were divided into four equal groups, including control, exercise, Curcumin and Curcumin-exercise groups. Ethanol was gavaged to all groups (g kg-1) for four days. Then, the renunciation period (four days) started. The exercise period included two weeks, each week included five sessions of exhaustive swimming. Curcumin supplementation (50 mg kg-1) was used with trainings. Results: Curcumin supplementation demonstrated significant decreases in expression of PDGF-BB (P = 0. 025) and TGF-β 1 (P = 0. 033) genes. In exercise groups, significant decreases were seen in expression of PDGF-BB (P = 0. 007) and TGF-β 1 (P = 0. 001) genes. Interaction of exercise and Curcumin resulted in significant decreases in expression of PDGFBB (P = 0. 040) and TGF-β 1 (P = 0. 013) genes. Conclusions: In conclusion, expression decreases in PDGF-BB and TGF-β 1 genes suggest that exercise and Curcumin consumption can protect hepatic tissues through controlling hepatic satellite cell (HSC) activation, preventing negative effects of Ethanol.

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    APA: Copy

    Dalvand, Hoseyn, Hematfar, Ahmad, & BEHPOOR, NASER. (2020). Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β 1 Gene Expressions in Alcoholic Rats. NUTRITION AND FOOD SCIENCES RESEARCH, 7(1), 33-40. SID. https://sid.ir/paper/698014/en

    Vancouver: Copy

    Dalvand Hoseyn, Hematfar Ahmad, BEHPOOR NASER. Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β 1 Gene Expressions in Alcoholic Rats. NUTRITION AND FOOD SCIENCES RESEARCH[Internet]. 2020;7(1):33-40. Available from: https://sid.ir/paper/698014/en

    IEEE: Copy

    Hoseyn Dalvand, Ahmad Hematfar, and NASER BEHPOOR, “Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β 1 Gene Expressions in Alcoholic Rats,” NUTRITION AND FOOD SCIENCES RESEARCH, vol. 7, no. 1, pp. 33–40, 2020, [Online]. Available: https://sid.ir/paper/698014/en

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