THE EFFECTS OF METHYLPHENIDATE ADMINISTRATION ON THE HISTOLOGICAL ALTERATIONS OF THE LYMPHATIC SYSTEM IN THE MICE

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LOUEI MONFARED ALI; HAMOONNAVARD SAHAR

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:9 (114) Page(s): 107-116

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Title

THE EFFECTS OF METHYLPHENIDATE ADMINISTRATION ON THE HISTOLOGICAL ALTERATIONS OF THE LYMPHATIC SYSTEM IN THE MICE

Author(s)

LOUEI MONFARED ALI | HAMOONNAVARD SAHAR | Issue Writer Certificate

Keywords

HISTOLOGICAL CHANGESQ1

LYMPHATIC SYSTEMQ1

MICEQ1

METHYLPHENIDATEQ1

Abstract

Background: The LYMPHATIC SYSTEM as a key component in the organism's body can be affected by used drugs. METHYLPHENIDATE or Ritalin is widely used for treatment of behavioral disorders in children and some depressed people. This study carried out to examine the immunotoxic effects of Ritalin.Materials and Methods: A total of 16 healthy adult female MICE were selected and randomly divided into a control and three experimental groups. The experimental groups received Ritalin as 0.5, 5 and 50 mg/kg body weight and control groups received distillated water by gavage method for 21 consecutive days. At the end of experiment, the structure and function of the lymphoid organs were evaluated. Results were analyzed by ANOVA and Duncan’s test (p<0.05).Results: Significant alterations including a reduction in the size and number of lymphoid follicles, increasing in the megakaryocytes numbers as well as spleen capsular thickens were seen following Ritalin administration. The atrophy of the lymph nodes together with significant reduction in the number and size of lymph follicles but an increasing in the parenchyma hyperemia were seen. Also lymphocyte numbers increased while the monocytes numbers decreased (p<0.05).Conclusion: The consumption of Ritalin could be exerted detrimental effects on the lymphoid organs in the mouse model.

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APA: Copy

HAMOONNAVARD, SAHAR. (2016). THE EFFECTS OF METHYLPHENIDATE ADMINISTRATION ON THE HISTOLOGICAL ALTERATIONS OF THE LYMPHATIC SYSTEM IN THE MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(9 (114)), 107-116. SID. https://sid.ir/paper/69836/en

Vancouver: Copy

HAMOONNAVARD SAHAR. THE EFFECTS OF METHYLPHENIDATE ADMINISTRATION ON THE HISTOLOGICAL ALTERATIONS OF THE LYMPHATIC SYSTEM IN THE MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(9 (114)):107-116. Available from: https://sid.ir/paper/69836/en

IEEE: Copy

SAHAR HAMOONNAVARD, “THE EFFECTS OF METHYLPHENIDATE ADMINISTRATION ON THE HISTOLOGICAL ALTERATIONS OF THE LYMPHATIC SYSTEM IN THE MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 9 (114), pp. 107–116, 2016, [Online]. Available: https://sid.ir/paper/69836/en

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