COMPARISON OF RADIATION-INDUCED BYSTANDER EFFECT IN QU-DB CELLS AFTER ACUTE AND FRACTIONATED IRRADIATION: AN IN VITRO STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOLEYMANIFARD SHOKOUHOZAMAN; BAHREYNI TOOSI MOHAMMAD TAGHI; KAMRAN SAMANI ROGHAYEH; MOHEBBI SHOKOUFEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2016 | Volume:18 | Issue:3 (71) Page(s): 346-352

Download Full-Text

View:

455

Download:

341

Cites:

Information Journal Paper

Title

COMPARISON OF RADIATION-INDUCED BYSTANDER EFFECT IN QU-DB CELLS AFTER ACUTE AND FRACTIONATED IRRADIATION: AN IN VITRO STUDY

Author(s)

SOLEYMANIFARD SHOKOUHOZAMAN | BAHREYNI TOOSI MOHAMMAD TAGHI | KAMRAN SAMANI ROGHAYEH | MOHEBBI SHOKOUFEH | Issue Writer Certificate

Keywords

BYSTANDER EFFECTS

DOSE FRACTIONATION

MICRONUCLEUS ASSAY

RADIATION

Abstract

Objective: RADIATION effects induced in non-irradiated cells are termed RADIATION-induced BYSTANDER EFFECTS (RIBE). The present study intends to examine the RIBE response of QU-DB bystander cells to first, second and third RADIATION fractions and compare their cumulative outcome with an equal, single acute dose.Materials and Methods: This experimental study irradiated three groups of target cells for one, two and three times with 60Co gamma rays. One hour after irradiation, we transferred their culture media to non-irradiated (bystander) cells. We used the cytokinesis block MICRONUCLEUS ASSAY to evaluate RIBE response in the bystander cells. The numbers of micronuclei generated in bystander cells were determined.Results: RIBE response to single acute doses increased up to 4 Gy, then decreased, and finally at the 8 Gy dose disappeared. The second and third fractions induced RIBE in bystander cells, except when RIBE reached to the maximum level at the first fraction.We split the 4 Gy acute dose into two fractions, which decreased the RIBE response.However, fractionation of 6 Gy (into two fractions of 3 Gy or three fractions of 2 Gy) had no effect on RIBE response. When we split the 8 Gy acute dose into two fractions we observed RIBE, which had disappeared following the single 8 Gy dose.Conclusion: The impact of DOSE FRACTIONATION on RIBE induced in QU-DB cells depended on the RIBE dose-response relationship. Where RIBE increased proportionally with the dose, fractionation reduced the RIBE response. In contrast, at high doses where RIBE decreased proportionally with the dose, fractionation either did not change RIBE (at 6 Gy) or increased it (at 8 Gy).

Cites

ASSESSMENT OF THE DOSE-RESPONSE RELATIONSHIP OF RADIATION-INDUCED BYSTANDER EFFECT IN TWO CELL LINES EXPOSED TO HIGH DOSES OF IONIZING RADIATION (6 AND 8 GY)

References

THE ROLE OF TARGET AND BYSTANDER CELLS IN DOSE-RESPONSE RELATIONSHIP OF RADIATION-INDUCED BYSTANDER EFFECTS IN TWO CELL LINES

Cite

APA: Copy

SOLEYMANIFARD, SHOKOUHOZAMAN, BAHREYNI TOOSI, MOHAMMAD TAGHI, KAMRAN SAMANI, ROGHAYEH, & MOHEBBI, SHOKOUFEH. (2016). COMPARISON OF RADIATION-INDUCED BYSTANDER EFFECT IN QU-DB CELLS AFTER ACUTE AND FRACTIONATED IRRADIATION: AN IN VITRO STUDY. CELL JOURNAL (YAKHTEH), 18(3 (71)), 346-352. SID. https://sid.ir/paper/698594/en

Vancouver: Copy

SOLEYMANIFARD SHOKOUHOZAMAN, BAHREYNI TOOSI MOHAMMAD TAGHI, KAMRAN SAMANI ROGHAYEH, MOHEBBI SHOKOUFEH. COMPARISON OF RADIATION-INDUCED BYSTANDER EFFECT IN QU-DB CELLS AFTER ACUTE AND FRACTIONATED IRRADIATION: AN IN VITRO STUDY. CELL JOURNAL (YAKHTEH)[Internet]. 2016;18(3 (71)):346-352. Available from: https://sid.ir/paper/698594/en

IEEE: Copy

SHOKOUHOZAMAN SOLEYMANIFARD, MOHAMMAD TAGHI BAHREYNI TOOSI, ROGHAYEH KAMRAN SAMANI, and SHOKOUFEH MOHEBBI, “COMPARISON OF RADIATION-INDUCED BYSTANDER EFFECT IN QU-DB CELLS AFTER ACUTE AND FRACTIONATED IRRADIATION: AN IN VITRO STUDY,” CELL JOURNAL (YAKHTEH), vol. 18, no. 3 (71), pp. 346–352, 2016, [Online]. Available: https://sid.ir/paper/698594/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops