INVESTIGATION OF ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CHELIDONIUM MAJUS ON PTZ INDUCED KINDLING IN MALE MICE

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Namvar Aghdash Simin; MOKHTARI MANSOURE

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Journal: Journal of Arak University Medical Sciences Year:2016 | Volume:18 | Issue:12 (105) Page(s): 74-81

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Title

INVESTIGATION OF ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CHELIDONIUM MAJUS ON PTZ INDUCED KINDLING IN MALE MICE

Author(s)

Namvar Aghdash Simin | MOKHTARI MANSOURE | Issue Writer Certificate

Keywords

SEIZUREQ2

EPILEPSYQ2

PENTYLENETETRAZOLEQ3

CHELIDONIUM MAJUSQ2

Abstract

Background: Traditional medicinal herbs have remained as a component of disease treatment system of many societies in the world. Today, many scientists have paid attention to the use of medicinal herbs in the treatment of epileptic SEIZUREs, because EPILEPSY is one of the most common neuropsychological disorders in the world that have many serious physical, psychological, social, and economic consequences. The aim of this study was to investigate the effect of CHELIDONIUM MAJUS extract in the treatment of SEIZURE.Materials and Methods: In this study 40 mice have been randomly chosen and divided into 5 groups including a control group that received only pentylenetetrazol, sham group that received distilled water and 3 experimental groups received aqueous extract of CHELIDONIUM MAJUS in doses of 50, 100 and 150 mg/kg for 4 weeks. 30 minutes after gavage with different doses of the extract or distilled water, pentylenetetrazol was injected to experimental and sham groups. Animals immediately were transferred to a special cage and the SEIZURE behaviors and parameters were recorded by a camera. Then, the different phases of SEIZURE, latency time for onset of SEIZURE and SEIZURE duration were evaluated.Results: Data analysis indicated that the aqueous extract of CHELIDONIUM MAJUS had a significant effect on PTZ-induced SEIZURE. Therapy by this extract increases latency time for onset of SEIZURE and prevents progress of SEIZURE phases.Conclusion: The attained results showed that CHELIDONIUM MAJUS extract has anticonvulsant effect on PTZ- induced SEIZURE. Thus, it may be used in SEIZURE treatment.

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APA: Copy

Namvar Aghdash, Simin, & MOKHTARI, MANSOURE. (2016). INVESTIGATION OF ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CHELIDONIUM MAJUS ON PTZ INDUCED KINDLING IN MALE MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 18(12 (105)), 74-81. SID. https://sid.ir/paper/69862/en

Vancouver: Copy

Namvar Aghdash Simin, MOKHTARI MANSOURE. INVESTIGATION OF ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CHELIDONIUM MAJUS ON PTZ INDUCED KINDLING IN MALE MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;18(12 (105)):74-81. Available from: https://sid.ir/paper/69862/en

IEEE: Copy

Simin Namvar Aghdash, and MANSOURE MOKHTARI, “INVESTIGATION OF ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CHELIDONIUM MAJUS ON PTZ INDUCED KINDLING IN MALE MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 18, no. 12 (105), pp. 74–81, 2016, [Online]. Available: https://sid.ir/paper/69862/en

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