Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L. ) Wettst

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Columba Palomares Maria C.; Montiel Ruiz Rosa Mariana; Sanchez Lucia Corona; Palafox Gante Daniel; Rodriguez Lopez Veronica

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Journal Paper

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Journal: Avicenna Journal of Phytomedicine Year:2021 | Volume:11 | Issue:2 Page(s): 101-108

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Information Journal Paper

Title

Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L. ) Wettst

Author(s)

Keywords

Russelia coccinea

Plantaginaceae

Anti-inflammatory activity

Antinociceptive activity

Organic extracts

Antioxidant

Abstract

Objective: Some species of the Russelia genus have been used different illnesses associated with pain and inflammation. The aim of this work was to characterize the biological activities (anti-inflammatory and analgesic) and Antioxidant capacity of methanol and dichloromethane extracts of Russelia coccinea. Materials and Methods: In this study, topical Anti-inflammatory activity was tested in an in vivo model of 12-O-tetradecanoylphorbol acetate (TPA) induced mouse ear edema of Organic extracts (doses: 0. 03, 0. 1 and 0. 3 mg/ear). The Antinociceptive activity was assessed using the formalin test in mice of Organic extracts (doses: 56, 100 and 300 mg/kg). Moreover, the Antioxidant capacity of the extracts was determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2′-azinobis (3-ethylbenzothiaziline-6-sulfonate) (ABTS) and ferric reducing Antioxidant power (FRAP) assays. Results: Methanol (RcM) and dichloromethane (RcD) extracts of the R. coccinea aerial parts were found to inhibit ear edema (48. 95 and 40. 13%, respectively) at a dose of 0. 3 mg/ear. Acute treatment with RcM produced a significant antinociceptive effect in the late phase of formalin-induced nociception. Moreover, RcM at doses of 56, 100 and 300 mg/kg showed a significant antinociceptive effect through the early and late phases in the formalin test. RcM and RcD showed weak Antioxidant capacities in the ABTS and DPPH assays; however, when their reducing capacity was evaluated by the FRAP assay, RcM showed a reducing activity similar to Camellia sinensis standard at the proven concentration of 1000 μ g/ml. Conclusion: According to the experimental findings, the Organic extracts of R. coccinea display remarkable antinociceptive and anti-inflammatory activities.

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APA: Copy

Columba Palomares, Maria C., Montiel Ruiz, Rosa Mariana, Sanchez, Lucia Corona, Palafox Gante, Daniel, & Rodriguez Lopez, Veronica. (2021). Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L. ) Wettst. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(2), 101-108. SID. https://sid.ir/paper/698765/en

Vancouver: Copy

Columba Palomares Maria C., Montiel Ruiz Rosa Mariana, Sanchez Lucia Corona, Palafox Gante Daniel, Rodriguez Lopez Veronica. Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L. ) Wettst. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(2):101-108. Available from: https://sid.ir/paper/698765/en

IEEE: Copy

Maria C. Columba Palomares, Rosa Mariana Montiel Ruiz, Lucia Corona Sanchez, Daniel Palafox Gante, and Veronica Rodriguez Lopez, “Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L. ) Wettst,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 2, pp. 101–108, 2021, [Online]. Available: https://sid.ir/paper/698765/en

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