TH1/TH2 CYTOKINE PROFILE AND ITS DIAGNOSTIC VALUE IN MYCOPLASMA PNEUMONIAE PNEUMONIA

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LI WEI; LIU YUJIE; ZHAO XIAO LE; SHANG SHI QIANG; WU LANG; QING YE; XU HUI

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Journal: Iranian Journal of Pediatrics Year:2016 | Volume:26 | Issue:1 Page(s): 0-0

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Title

TH1/TH2 CYTOKINE PROFILE AND ITS DIAGNOSTIC VALUE IN MYCOPLASMA PNEUMONIAE PNEUMONIA

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Keywords

CYTOKINES

PNEUMONIA

CHILDREN

M. PNEUMONIA

Abstract

Background: The levels of Th1/Th2 cytokine can alter in pathogenic infection in CHILDREN with PNEUMONIA.Objectives: To evaluate Th1/Th2 cytokine profile and its diagnostic value in M. PNEUMONIAe PNEUMONIA in CHILDREN.Patients and Methods: CHILDREN with M. PNEUMONIAe mono-infection and 30 healthy CHILDREN were tested with CYTOKINES assay. We used real time PCR to detect M. PNEUMONIAe in CHILDREN with PNEUMONIA.Results: M. PNEUMONIAe test was positive in 2188 (16.62%) out of 13161 PNEUMONIA CHILDREN. CHILDREN aged 5 - 9 years had the highest rate and summer was a season with high rate of M. PNEUMONIAe incidence in Zhejiang province. During the course of study, in 526 PNEUMONIA CHILDREN with M. PNEUMONIAe mono-infection and 30 healthy CHILDREN CYTOKINES assay was performed. IL-2 level of M. PNEUMONIAe PNEUMONIA CHILDREN was lower than that of healthy CHILDREN (median levels, pg/mL: IL-2: 3.2 vs.5.7, P=0.00), while IL-4, IL-10 and IFN-γ were higher than in healthy CHILDREN (median levels, pg/mL: IL-4: 3.2 vs.1.5, P=0.00; IL-10: 5.6 vs.2.5, P=0.001; IFN-g: 20.4 vs.4.8, P=0.001).Conclusions: IL-2 decreases and IL-4, IL-10 and IFN-g increase in CHILDREN with M. PNEUMONIAe PNEUMONIA, which has a promising prospect in diagnosis of this disease in clinical practice.

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APA: Copy

LI, WEI, LIU, YUJIE, ZHAO, XIAO LE, SHANG, SHI QIANG, WU, LANG, QING, YE, & XU, HUI. (2016). TH1/TH2 CYTOKINE PROFILE AND ITS DIAGNOSTIC VALUE IN MYCOPLASMA PNEUMONIAE PNEUMONIA. IRANIAN JOURNAL OF PEDIATRICS, 26(1), 0-0. SID. https://sid.ir/paper/698796/en

Vancouver: Copy

LI WEI, LIU YUJIE, ZHAO XIAO LE, SHANG SHI QIANG, WU LANG, QING YE, XU HUI. TH1/TH2 CYTOKINE PROFILE AND ITS DIAGNOSTIC VALUE IN MYCOPLASMA PNEUMONIAE PNEUMONIA. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2016;26(1):0-0. Available from: https://sid.ir/paper/698796/en

IEEE: Copy

WEI LI, YUJIE LIU, XIAO LE ZHAO, SHI QIANG SHANG, LANG WU, YE QING, and HUI XU, “TH1/TH2 CYTOKINE PROFILE AND ITS DIAGNOSTIC VALUE IN MYCOPLASMA PNEUMONIAE PNEUMONIA,” IRANIAN JOURNAL OF PEDIATRICS, vol. 26, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/698796/en

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