The Effect of Iron Oxide Nanoparticles and Magnetic Field on Angiogenesis and Deregulation of Vegfa Gene After Ischemia Reperfusion in Rat

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Ghasemi Mina; KHAZAEI KOOHPAR ZEINAB; FALAHATI MOJTABA

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Title

The Effect of Iron Oxide Nanoparticles and Magnetic Field on Angiogenesis and Deregulation of Vegfa Gene After Ischemia Reperfusion in Rat

Author(s)

Ghasemi Mina | KHAZAEI KOOHPAR ZEINAB | FALAHATI MOJTABA | Issue Writer Certificate

Keywords

Iron oxide nanoparticlesQ1

Ischemia reperfusion (IR)Q1

Magnetic fieldQ1

Q-RT-PCRQ1

VegfaQ1

Abstract

Background and Aim: Prolonged ischemia in organs with high metabolic rates such as brain and heart is associated with deleterious effects. Therefore, nutritive distribution through angiogenesis after ischemia is necessary for repairing damaged region of tissue. In this study, the effects of Iron oxide nanoparticles and Magnetic field on angiogenesis after ischemia reperfusion (IR) in rat model have been investigated. Materials and Methods: In this experimental study, fifty male rats aged between 6-7 weeks at the 220-250gr weight were purchased from Tehran University. Animals were categorized in 5 groups including sham (ischemia reperfusion model), control, Iron oxide nanoparticles-treated, Magnetic fieldexposed, and combination therapy with Iron oxide nanoparticles and Magnetic field-exposed groups. Angiogenesis was evaluated in hippocampus of 5 groups after 4 days by H&E staining method. The expression of Vegfa gene was studied in 5 groups by Q-RT-PCR. Findings: Iron oxide nanoparticles as well as the Magnetic field induced angiogenesis during 4 days in animals after IR (p<0. 05), but their combination therapy did not show any significant difference compared to sham group during 4 days. Upregulation of Vegfa gene was observed in Iron oxide nanoparticles treated group and the Magnetic field exposed group significantly (p<0. 05) relative to ischemia reperfusion (IR) model. But overexpression of Vegfa gene in combination therapy group was not significant relative to ischemia reperfusion (IR) group. Conclusion: It seems that Iron oxide nanoparticles and Magnetic field can separately be two effective methods for angiogenesis after ischemia reperfusion (IR).

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APA: Copy

Ghasemi, Mina, KHAZAEI KOOHPAR, ZEINAB, & FALAHATI, MOJTABA. (2018). The Effect of Iron Oxide Nanoparticles and Magnetic Field on Angiogenesis and Deregulation of Vegfa Gene After Ischemia Reperfusion in Rat. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(3 (132) ), 83-93. SID. https://sid.ir/paper/69881/en

Vancouver: Copy

Ghasemi Mina, KHAZAEI KOOHPAR ZEINAB, FALAHATI MOJTABA. The Effect of Iron Oxide Nanoparticles and Magnetic Field on Angiogenesis and Deregulation of Vegfa Gene After Ischemia Reperfusion in Rat. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;21(3 (132) ):83-93. Available from: https://sid.ir/paper/69881/en

IEEE: Copy

Mina Ghasemi, ZEINAB KHAZAEI KOOHPAR, and MOJTABA FALAHATI, “The Effect of Iron Oxide Nanoparticles and Magnetic Field on Angiogenesis and Deregulation of Vegfa Gene After Ischemia Reperfusion in Rat,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 3 (132) , pp. 83–93, 2018, [Online]. Available: https://sid.ir/paper/69881/en

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