TO STUDY THE EFFECT OF CALCIUM PLUS VITAMIND SUPPLEMENTATION ON NITRIC OXIDE AND BIOMARKERS OF OXIDATIVE STRESS IN OVERWEIGHT AND OBESS WOMEN WITH POLYCYSTIC OVARY SYNDROME

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JAMILIAN MEHRI; BAKHSHAYESHY SOMAYEH

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:6 (111) Page(s): 27-36

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Title

TO STUDY THE EFFECT OF CALCIUM PLUS VITAMIND SUPPLEMENTATION ON NITRIC OXIDE AND BIOMARKERS OF OXIDATIVE STRESS IN OVERWEIGHT AND OBESS WOMEN WITH POLYCYSTIC OVARY SYNDROME

Author(s)

JAMILIAN MEHRI | BAKHSHAYESHY SOMAYEH | Issue Writer Certificate

Keywords

CALCIUMQ2

VITAMIN DQ1

SUPPLEMENTATIONQ1

POLYCYSTIC OVARY SYNDROMEQ1

METABOLIC PROFILESQ1

Abstract

Background: Few studies have examined the effects of CALCIUM plus VITAMIN Dsupplementation on METABOLIC PROFILES in overweight women with POLYCYSTIC OVARY SYNDROME (PCOS).This study was conducted to determine the effects of CALCIUM plus VITAMIN D SUPPLEMENTATIONon METABOLIC PROFILES among overweight women with PCOS.Materials and Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 104 overweight and obess women with PCOS. Participants were randomly assignedinto four groups to receive: 1) 1000 mg/d CALCIUM+vitamin D placebo; 2) 50000 IU/weeks VITAMIN D; 3) 1000 mg CALCIUM/d and 4) CALCIUM placebo+vitamin D placebo for 8 weeks. Fasting blood sampleswere taken at baseline and after 8 weeks intervention to measure METABOLIC PROFILES.Results: After administrating CALCIUM plus VITAMIN D SUPPLEMENTATION, a significant decrease was observed in serum insulin (-3.3±11.4 vs.-1.1±8.5, -1.4±3.0 and+3.1±6.1 mIU/ml, p=0.03), insulinresistance (-0.7±2.4 vs.-0.3±2.5, -0.2±0.6 and+0.8±1.9, p=0.04), malondialdehyde (-0.6±0.3 vs.-0.1±0.2, -0.5±0.2 and+0.6±0.4 μmol/L, p=0.009) and a significant rise was seen in total antioxidantcapacity (+35.2±21.7 vs.+22.5±37.7, +21.1±34.1 and -153.8±65.2 mmol/L, p=0.006) and glutathione (+216.0±79.3 vs.-47.5±60.2, +3.9±31.3 and -160.8±82.9 mmol/L, p=0.001) compared with VITAMIN D, CALCIUM and placebo groups.Conclusion: In conclusion, CALCIUM plus VITAMIN D SUPPLEMENTATION for eight weeks among women with PCOS had beneficial effects on METABOLIC PROFILES.

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APA: Copy

JAMILIAN, MEHRI, & BAKHSHAYESHY, SOMAYEH. (2016). TO STUDY THE EFFECT OF CALCIUM PLUS VITAMIND SUPPLEMENTATION ON NITRIC OXIDE AND BIOMARKERS OF OXIDATIVE STRESS IN OVERWEIGHT AND OBESS WOMEN WITH POLYCYSTIC OVARY SYNDROME. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(6 (111)), 27-36. SID. https://sid.ir/paper/69914/en

Vancouver: Copy

JAMILIAN MEHRI, BAKHSHAYESHY SOMAYEH. TO STUDY THE EFFECT OF CALCIUM PLUS VITAMIND SUPPLEMENTATION ON NITRIC OXIDE AND BIOMARKERS OF OXIDATIVE STRESS IN OVERWEIGHT AND OBESS WOMEN WITH POLYCYSTIC OVARY SYNDROME. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(6 (111)):27-36. Available from: https://sid.ir/paper/69914/en

IEEE: Copy

MEHRI JAMILIAN, and SOMAYEH BAKHSHAYESHY, “TO STUDY THE EFFECT OF CALCIUM PLUS VITAMIND SUPPLEMENTATION ON NITRIC OXIDE AND BIOMARKERS OF OXIDATIVE STRESS IN OVERWEIGHT AND OBESS WOMEN WITH POLYCYSTIC OVARY SYNDROME,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 6 (111), pp. 27–36, 2016, [Online]. Available: https://sid.ir/paper/69914/en

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