PREPARATION AND EVALUATION OF IMMUNOGENICITY OF CHITOSAN NANOPARTICLES CONTAINING TETANOTOXIN IN COMPARISON WITH FREUND'S ADJUVANT IN MOUSE MODEL FOR IMPROVEMENT OF TETANUS VACCINE AFTER SUBCUTANEOUS INJECTION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHALAVAND MAJDEDIN; SAADATI MOJTABA; SALIMIAN JAFAR; ABBASI EBRAHIM; Tarverdizadeh Yosuf; DOROSTKAR SARI ROUHOLLAH; FASIHI RAMANDI MAHDI; ZAND ALI MOHAMMAD

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2017 | Volume:11 | Issue:2 Page(s): 19-28

Download Full-Text

View:

239

Download:

Cites:

Information Journal Paper

Title

PREPARATION AND EVALUATION OF IMMUNOGENICITY OF CHITOSAN NANOPARTICLES CONTAINING TETANOTOXIN IN COMPARISON WITH FREUND'S ADJUVANT IN MOUSE MODEL FOR IMPROVEMENT OF TETANUS VACCINE AFTER SUBCUTANEOUS INJECTION

Author(s)

Keywords

NANOPARTICLES

TETANUS

CHITOSAN

FREUND’S ADJUVANT

Abstract

Background and Objectives: TETANUS is a deadly zoonotic infectious disease. For nearly a century, TETANUS vaccine has been produced and used. This study was carried out with the aim of preparation and evaluation of immunogenicity of CHITOSAN NANOPARTICLES containing tetanotoxin in comparison with Freund's adjuvant in mouse model for improvement of TETANUS vaccine after subcutaneous onjection.Methods: In this experimental study, CHITOSAN NANOPARTICLES synthesis containing TETANUS toxoid was performed using ionic gelation method. The morphology of NANOPARTICLES was investigated using SEM and AFM, then, the NANOPARTICLES were subcutaneously injected into mice and two weeks after the end of injection, blood was taken. Antibody titer was measured by indirect ELISA. Data were analyzed using one-way one-way ANOVA and Tukey test at significance level of p<0.05.Results: High-load antigen (uniform spherical morphology and the mean size of 144), were encapsulated in CHITOSAN NANOPARTICLES. After serum analysis, IgG antibody titer was significantly different between the mice that received antigen as nanoparticle and the control group, but no significant difference was observed in the antigen with FREUND’S ADJUVANT group.Conclusion: Based on the results of this study, TETANUS toxoid injection using nanoproces is able to induce humoral immune response almost equal to FREUND’S ADJUVANT and can be an appropriate alternative.

Cites

No record.

References

No record.

Cite

APA: Copy

GHALAVAND, MAJDEDIN, SAADATI, MOJTABA, SALIMIAN, JAFAR, ABBASI, EBRAHIM, Tarverdizadeh, Yosuf, DOROSTKAR SARI, ROUHOLLAH, FASIHI RAMANDI, MAHDI, & ZAND, ALI MOHAMMAD. (2017). PREPARATION AND EVALUATION OF IMMUNOGENICITY OF CHITOSAN NANOPARTICLES CONTAINING TETANOTOXIN IN COMPARISON WITH FREUND'S ADJUVANT IN MOUSE MODEL FOR IMPROVEMENT OF TETANUS VACCINE AFTER SUBCUTANEOUS INJECTION. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 11(2), 19-28. SID. https://sid.ir/paper/700248/en

Vancouver: Copy

GHALAVAND MAJDEDIN, SAADATI MOJTABA, SALIMIAN JAFAR, ABBASI EBRAHIM, Tarverdizadeh Yosuf, DOROSTKAR SARI ROUHOLLAH, FASIHI RAMANDI MAHDI, ZAND ALI MOHAMMAD. PREPARATION AND EVALUATION OF IMMUNOGENICITY OF CHITOSAN NANOPARTICLES CONTAINING TETANOTOXIN IN COMPARISON WITH FREUND'S ADJUVANT IN MOUSE MODEL FOR IMPROVEMENT OF TETANUS VACCINE AFTER SUBCUTANEOUS INJECTION. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2017;11(2):19-28. Available from: https://sid.ir/paper/700248/en

IEEE: Copy

MAJDEDIN GHALAVAND, MOJTABA SAADATI, JAFAR SALIMIAN, EBRAHIM ABBASI, Yosuf Tarverdizadeh, ROUHOLLAH DOROSTKAR SARI, MAHDI FASIHI RAMANDI, and ALI MOHAMMAD ZAND, “PREPARATION AND EVALUATION OF IMMUNOGENICITY OF CHITOSAN NANOPARTICLES CONTAINING TETANOTOXIN IN COMPARISON WITH FREUND'S ADJUVANT IN MOUSE MODEL FOR IMPROVEMENT OF TETANUS VACCINE AFTER SUBCUTANEOUS INJECTION,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 11, no. 2, pp. 19–28, 2017, [Online]. Available: https://sid.ir/paper/700248/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops