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Information Journal Paper

Title

HAIR FOLLICLE GENERATION BY INJECTIONS OF ADULT HUMAN FOLLICULAR EPITHELIAL AND DERMAL PAPILLA CELLS INTO NUDE MICE

Pages

  259-268

Abstract

 Objective: DERMAL PAPILLA and hair epithelial stem cells regulate hair formation and the growth cycle. Damage to or loss of these cells can cause hair loss. Although several studies claim to reconstitute hairs using rodent cells in an animal model, additional research is needed to develop a stable human hair follicle reconstitution protocol. In this study, we have evaluated hair induction by injecting adult cultured human DERMAL PAPILLA cells and a mixture of hair epithelial and DERMAL PAPILLA cells in a mouse model.Materials and Methods: In this experimental study, discarded human scalp skins were used to obtain DERMAL PAPILLA and hair epithelial cells. After separation, cells were cultured and assessed for their characteristics. We randomly allocated 15 C57BL/6 nude mice into three groups that received injections in their dorsal skin. The first group received cultured DERMAL PAPILLA cells, the second group received a mixture of cultured epithelial and DERMAL PAPILLA cells, and the third group (control) received a placebo [phosphate-buffered saline (PBS-)].Results: Histopathologic examination of the injection sites showed evidence of hair growth in samples that received cells compared with the control group. However, the group that received epithelial and DERMAL PAPILLA cells had visible evidence of hair growth. PKH tracing confirmed the presence of transplanted cells in the new hair.Conclusion: Our data showed that injection of a combination of adult human cultured DERMAL PAPILLA and epithelial cells could induce hair growth in nude mice. This study emphasized that the combination of human adult cultured DERMAL PAPILLA and epithelial cells could induce new hair in nude mice.

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    APA: Copy

    Nilforoushzadeh, Mohammadali, RAHIMI JAMEH, ELHAM, JAFFARY, FARIBA, ABOLHASANI, EHSAN, KESHTMAND, GELAVIZH, ZARKOB, HAJAR, MOHAMMADI, PARVANEH, & AGHDAMI, NASSER. (2017). HAIR FOLLICLE GENERATION BY INJECTIONS OF ADULT HUMAN FOLLICULAR EPITHELIAL AND DERMAL PAPILLA CELLS INTO NUDE MICE. CELL JOURNAL (YAKHTEH), 19(2), 259-268. SID. https://sid.ir/paper/700280/en

    Vancouver: Copy

    Nilforoushzadeh Mohammadali, RAHIMI JAMEH ELHAM, JAFFARY FARIBA, ABOLHASANI EHSAN, KESHTMAND GELAVIZH, ZARKOB HAJAR, MOHAMMADI PARVANEH, AGHDAMI NASSER. HAIR FOLLICLE GENERATION BY INJECTIONS OF ADULT HUMAN FOLLICULAR EPITHELIAL AND DERMAL PAPILLA CELLS INTO NUDE MICE. CELL JOURNAL (YAKHTEH)[Internet]. 2017;19(2):259-268. Available from: https://sid.ir/paper/700280/en

    IEEE: Copy

    Mohammadali Nilforoushzadeh, ELHAM RAHIMI JAMEH, FARIBA JAFFARY, EHSAN ABOLHASANI, GELAVIZH KESHTMAND, HAJAR ZARKOB, PARVANEH MOHAMMADI, and NASSER AGHDAMI, “HAIR FOLLICLE GENERATION BY INJECTIONS OF ADULT HUMAN FOLLICULAR EPITHELIAL AND DERMAL PAPILLA CELLS INTO NUDE MICE,” CELL JOURNAL (YAKHTEH), vol. 19, no. 2, pp. 259–268, 2017, [Online]. Available: https://sid.ir/paper/700280/en

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