Evaluating the Anti-proliferative Effects of Nanoemulsion Containing Licorice Extract and Lavender Essential Oil on Cancer

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Karimi Taheri Zohreh; Aarabi Mohammad Hosein; Nazari Alam Ali; NEJATI MAJID; SHAYESTEHPOUR MOHAMMAD; GILASI HAMID REZA; SALEHI AFSHIN; Shahaboddin Mohammad Esmaeil

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Journal Paper

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Journal: Journal of Arak University Medical Sciences Year:2021 | Volume:24 | Issue:1 (149) Page(s): 84-87

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Title

Evaluating the Anti-proliferative Effects of Nanoemulsion Containing Licorice Extract and Lavender Essential Oil on Cancer

Author(s)

Keywords

Emulsions

Lavender

Licorice

Anti-infective agents

Anticancer agent

Abstract

Background and Aim Despite the anti-cancer and antimicrobial properties of Licorice extract and Lavender essential oil, some factors, such as low bioavailability and biodegradable, limit their therapeutic use. Using nanoparticles is a method to overcome these restrictions. This study aimed to investigate the antiproliferative effects of nanoemulsion containing Licorice extract and Lavender essential oil on cancer cells; we also evaluated its antimicrobial properties in vitro. Methods & Materials In this experimental study, nanoEmulsions, containing Licorice extract and Lavender essential oil were developed by the spontaneous emulsion method. The anti-proliferative effect of nanoemulsion was investigated using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) colorimetric method on two cell lines HepG2 and SK-MEL-3. To measure the antimicrobial effect of 4 standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Minimum Inhibitory Concentration (MIC) method was used. Ethical Considerations This study was approved by the Ethics Committee of Kashan University of Medical Sciences (Code: IR. KAUMS. MEDNT. REC. 1396. 106). Results The results of MTT test on HepG2 cells indicated that the concentrations of 630, 1250, and 2500 μ g/mL nanoEmulsions caused toxicity to the cell and led to the death of >50% of the cells (IC50=401μ g/ mL; P<0. 05). Evaluating SK-MEL3 cells revealed that except for 75 μ g of nanoemulsion, other concentrations induced death in >50% of the cells (IC50 = 82 μ g/mL; P<0. 05). In addition, nanoEmulsions, with antimicrobial properties, were studied in 4 strains of bacteria; the highest antimicrobial properties were observed in Staphylococcus epidermidis. Conclusion Nanoemulsion containing Licorice extract and Lavender essential oil presents antimicrobial and antiproliferative effects on the two cell lines studied. The current study results indicated that the nano emulsification of Lavender essential oil and Licorice extract can enhance their biological impact; thus, they can be used as a drug formulation.

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Evaluation of biological properties of Rosa damascene essential oil nanoemulsion in vitro

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APA: Copy

Karimi Taheri, Zohreh, Aarabi, Mohammad Hosein, Nazari Alam, Ali, NEJATI, MAJID, SHAYESTEHPOUR, MOHAMMAD, GILASI, HAMID REZA, SALEHI, AFSHIN, & Shahaboddin, Mohammad Esmaeil. (2021). Evaluating the Anti-proliferative Effects of Nanoemulsion Containing Licorice Extract and Lavender Essential Oil on Cancer. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 24(1 (149) ), 84-87. SID. https://sid.ir/paper/700400/en

Vancouver: Copy

Karimi Taheri Zohreh, Aarabi Mohammad Hosein, Nazari Alam Ali, NEJATI MAJID, SHAYESTEHPOUR MOHAMMAD, GILASI HAMID REZA, SALEHI AFSHIN, Shahaboddin Mohammad Esmaeil. Evaluating the Anti-proliferative Effects of Nanoemulsion Containing Licorice Extract and Lavender Essential Oil on Cancer. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2021;24(1 (149) ):84-87. Available from: https://sid.ir/paper/700400/en

IEEE: Copy

Zohreh Karimi Taheri, Mohammad Hosein Aarabi, Ali Nazari Alam, MAJID NEJATI, MOHAMMAD SHAYESTEHPOUR, HAMID REZA GILASI, AFSHIN SALEHI, and Mohammad Esmaeil Shahaboddin, “Evaluating the Anti-proliferative Effects of Nanoemulsion Containing Licorice Extract and Lavender Essential Oil on Cancer,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 24, no. 1 (149) , pp. 84–87, 2021, [Online]. Available: https://sid.ir/paper/700400/en

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