Antioxidant effects of ethyl acetate extract of Akbari pistachio kernel on toxic effects arising from taking cisplatin (a chemotherapy medication) in rats

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SADEGHIAN FATEMEH; Pourtavakoli Ashkan; Kazemi Faezeh; SHEIKH FATHOLLAHI MAHMOOD; KHOSHDEL ALIREZA

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Journal Paper

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Journal: Pistachio and Health Journal Year:2021 | Volume:4 | Issue:3 Page(s): 7-15

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Title

Antioxidant effects of ethyl acetate extract of Akbari pistachio kernel on toxic effects arising from taking cisplatin (a chemotherapy medication) in rats

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Keywords

pistachio kernel

antioxidant

cisplatin

cancer

Abstract

Background and purpose: cisplatin is an important anticancer drug and despite its beneficial clinical effects in the treatment of cancer, it has toxic side effects owing to the production of free radicals. Pistachio is one of the plants having compounds with antioxidant properties and contains vitamins E and C, beta-carotene, various antioxidants, gamma tocopherol, quercetin, flavonoids, lutein, xanthine and minerals such as copper and selenium. pistachio kernel extract contains multi-purpose phenolic compounds and can act as a free radical scavenger. Method: This experimental study was conducted on 36 male Wistar rats for 15 days. The rats were randomly divided into six 6-rat groups. Group 1 was the control group including healthy rats receiving DMSO (Dimethyl sulfoxide). Group 2 was healthy rats receiving 200 mg/kg body weight of ethyl acetate extract of pistachio kernel for 15 days. Group 3 was the healthy rats receiving 400 mg/kg body weight of ethyl acetate extract of pistachio kernel for 15 days. Group 4 was rats receiving cisplatin at a dose of 10 mg/kg body weight by intraperitoneal injection on the tenth day of untreated experiment. Group 5 was the rats receiving cisplatin at a dose of 200 mg/kg body weight from ethyl acetate extract of pistachio kernel for 15 days. Finally, group 6 included the rats receiving cisplatin at a dose of 400 mg/kg body weight from ethyl acetate extract of pistachio kernel for 15 days. After 15 days, blood samples were taken from the corners of the rats’ eyes and after isolating the serum was revived and concentration of Malondialdehyde (MDA), glutathione and the activity of enzymes including superoxide dismutase (SOD), catalase (Cat), glutathione peroxidase (Gpx) and total antioxidant capacity (TAC) was measured in the serum. Results: In groups 2 and 3 receiving only the extract, a significant decrease in serum levels of SOD and Cat and a significant increase in TAC were observed compared to that of the control group (P< 0. 001). Moreover, in group 4 receiving only cisplatin, a significant decrease was observed in serum levels of Gpx, Cat, SOD and TAC, and a significant decrease was also observed in MDA compared to that of the control group (P< 0. 001). In addition, the high dose of the extract in group 3 led to a significant decrease in MDA compared to that of the control group, yet the low dose of extract in group 2 caused a significant decrease in Gpx enzyme compared to that of the control group (P< 0. 001). Discussion: The results of this study showed that the hydro-alcoholic extract of pistachio kernel has protective and modulating effects against cisplatin toxicity in rats and due to its antioxidant properties, it increased the activity of antioxidant enzymes.

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APA: Copy

SADEGHIAN, FATEMEH, Pourtavakoli, Ashkan, Kazemi, Faezeh, & SHEIKH FATHOLLAHI, MAHMOOD. (2021). Antioxidant effects of ethyl acetate extract of Akbari pistachio kernel on toxic effects arising from taking cisplatin (a chemotherapy medication) in rats. PISTACHIO AND HEALTH JOURNAL, 4(3), 7-15. SID. https://sid.ir/paper/700724/en

Vancouver: Copy

SADEGHIAN FATEMEH, Pourtavakoli Ashkan, Kazemi Faezeh, SHEIKH FATHOLLAHI MAHMOOD. Antioxidant effects of ethyl acetate extract of Akbari pistachio kernel on toxic effects arising from taking cisplatin (a chemotherapy medication) in rats. PISTACHIO AND HEALTH JOURNAL[Internet]. 2021;4(3):7-15. Available from: https://sid.ir/paper/700724/en

IEEE: Copy

FATEMEH SADEGHIAN, Ashkan Pourtavakoli, Faezeh Kazemi, and MAHMOOD SHEIKH FATHOLLAHI, “Antioxidant effects of ethyl acetate extract of Akbari pistachio kernel on toxic effects arising from taking cisplatin (a chemotherapy medication) in rats,” PISTACHIO AND HEALTH JOURNAL, vol. 4, no. 3, pp. 7–15, 2021, [Online]. Available: https://sid.ir/paper/700724/en

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