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Information Journal Paper

Title

Comparing the Efficacy of Methadone and Tincture of Opium in Controlling Agitation Caused by Withdrawal Syndrome in Opium-Addicted Patients in the Intensive Care Unit: A Randomized Trial Study

Pages

  69-76

Abstract

 Background: Few studies have been conducted regarding the comparison of the efficacy of Methadone and tincture of opium (TOP) in controlling agitation induced by withdrawal syndrome. Therefore, the current randomized trial study is carried out with the aim to evaluate comparisons on the efficacy of Methadone and TOP in controlling agitation caused by withdrawal syndrome in opium addicted patients in the Intensive care units (ICUs). Methods: This clinical trial study was conducted on 60 patients admitted to ICU of Shahid Bahonar Hospital, Kerman, Iran. After classification of the patients into two groups, the first and second groups consumed Methadone syrup (5 mg/ml) and TOP (10 mg/ml), respectively. Agitation in these patients was assessed through the Richmond Agitation-Sedation Scale (RASS). Vital signs were also assessed. Paired sample t-test and independent t-test were used for data analysis. Findings: In the current study, the administered dose of Methadone and TOP was 36. 17 ± 26. 99 and 112. 67 ± 102. 74 mg, respectively (P < 0. 010). Methadone administration led to a significant decrease of the patients’ vital signs, including systolic blood pressure, heart rate, respiratory rate, and Glasgow Coma Scale (GCS) (P < 0. 05). Though TOP administration decreased systolic blood pressure and GCS significantly (P < 0. 05), it had no effect on patients’ diastolic blood pressure, body temperature, heart rate, and respiratory rate (P > 0. 05). In total, no significant difference was detected between two groups regarding vital signs (P > 0. 05). However, a significant difference was seen between Methadone and TOP groups in terms of RASS score (P < 0. 01). Conclusion: According to the results of the current study, lower dose of Methadone, compared to TOP, could control agitation caused by opium withdrawal symptoms.

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    Cite

    APA: Copy

    SOHREVARDI, SEYED MOJTABA, Pournamdari, Mostafa, Salimi, Razieh, SARRAFZADEH, FARHAD, & AHMADINEJAD, MEHDI. (2020). Comparing the Efficacy of Methadone and Tincture of Opium in Controlling Agitation Caused by Withdrawal Syndrome in Opium-Addicted Patients in the Intensive Care Unit: A Randomized Trial Study. ADDICTION AND HEALTH, 12(2 ), 69-76. SID. https://sid.ir/paper/701881/en

    Vancouver: Copy

    SOHREVARDI SEYED MOJTABA, Pournamdari Mostafa, Salimi Razieh, SARRAFZADEH FARHAD, AHMADINEJAD MEHDI. Comparing the Efficacy of Methadone and Tincture of Opium in Controlling Agitation Caused by Withdrawal Syndrome in Opium-Addicted Patients in the Intensive Care Unit: A Randomized Trial Study. ADDICTION AND HEALTH[Internet]. 2020;12(2 ):69-76. Available from: https://sid.ir/paper/701881/en

    IEEE: Copy

    SEYED MOJTABA SOHREVARDI, Mostafa Pournamdari, Razieh Salimi, FARHAD SARRAFZADEH, and MEHDI AHMADINEJAD, “Comparing the Efficacy of Methadone and Tincture of Opium in Controlling Agitation Caused by Withdrawal Syndrome in Opium-Addicted Patients in the Intensive Care Unit: A Randomized Trial Study,” ADDICTION AND HEALTH, vol. 12, no. 2 , pp. 69–76, 2020, [Online]. Available: https://sid.ir/paper/701881/en

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