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Title

The Relationship Between Promoter Methylation of RASSF1A Gene and Prognosis of Patients Affected with Breast Cancer in Khuzestan Province

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Abstract

 Background: DNA methylation is one of the most frequent molecular changes that are associated with human cancers. Tumor suppressor genes are the important targets of hypermethylation in breast cancer and thus may result in cancer by deregulation of cell growth and division. Objectives: The purpose of this research was to compare the methylation pattern of the RASSF1A gene in cancerous and normal tissues. Methods: Twenty breast cancer patients with known clinicopathologic characteristics and 20 healthy women as control were studied for analysis of the methylation status of the RASSF1A gene promoter by methylation-specific polymerase chain reaction (MS-PCR) technique. Results: The findings showed that the frequency of RASSF1A promoter methylation was in 15% of tumor tissues and 5% of normal tissues. These results indicate that there isnostatistically significant relationship between the RASSF1A promoter methylation status of tumor tissues and normal tissues (P > 0. 05). Conclusions: Until now, the evidence for powerful methylation biomarkers is still incomplete and the recognized biomarkers require further validation.

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    APA: Copy

    MOHAMMADI ASL, JAVAD, GHANBARI MARDASI, FARIDEH, SAKI, GHASEM, RAHIM, FAKHER, RASHIDI, IRAN, RANJBARI, NASTARAN, Kheradmand, Parvin, Abromand, Mohammad, GHAVABESH, JASEM, & Fazeli, Kolsoum. (2020). The Relationship Between Promoter Methylation of RASSF1A Gene and Prognosis of Patients Affected with Breast Cancer in Khuzestan Province. GENE, CELL AND TISSUE, 7(1), 0-0. SID. https://sid.ir/paper/702106/en

    Vancouver: Copy

    MOHAMMADI ASL JAVAD, GHANBARI MARDASI FARIDEH, SAKI GHASEM, RAHIM FAKHER, RASHIDI IRAN, RANJBARI NASTARAN, Kheradmand Parvin, Abromand Mohammad, GHAVABESH JASEM, Fazeli Kolsoum. The Relationship Between Promoter Methylation of RASSF1A Gene and Prognosis of Patients Affected with Breast Cancer in Khuzestan Province. GENE, CELL AND TISSUE[Internet]. 2020;7(1):0-0. Available from: https://sid.ir/paper/702106/en

    IEEE: Copy

    JAVAD MOHAMMADI ASL, FARIDEH GHANBARI MARDASI, GHASEM SAKI, FAKHER RAHIM, IRAN RASHIDI, NASTARAN RANJBARI, Parvin Kheradmand, Mohammad Abromand, JASEM GHAVABESH, and Kolsoum Fazeli, “The Relationship Between Promoter Methylation of RASSF1A Gene and Prognosis of Patients Affected with Breast Cancer in Khuzestan Province,” GENE, CELL AND TISSUE, vol. 7, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/702106/en

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