AN IMPROVED AUTOMATED SETUP FOR SOLUBILITY DETERMINATION OF DRUGS (SHORT COMMUNICATION)

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GHANBARI AHMAD; SARBAZ YASHAR; JOUYBAN GHARAMALEKI VAHID; JOUYBAN GHARAMALEKI KARIM; SOLEYMANI JAFAR; JOUYBAN ABOLGHASEM

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Journal: PHARMACEUTICAL SCIENCES Year:2016 | Volume:22 | Issue:3 Page(s): 210-214

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Title

AN IMPROVED AUTOMATED SETUP FOR SOLUBILITY DETERMINATION OF DRUGS (SHORT COMMUNICATION)

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Keywords

AQUEOUS SOLUBILITY

DETERMINATION

DRUG

LASER MONITORING

Abstract

Background: Solubility of a DRUG/drug candidate is an essential information in the pharmaceutical area. Classical solubility DETERMINATION method used in the laboratories are expensive and time-consuming. Attempts were made to provide an automated solubility DETERMINATION setup based on a LASER MONITORING technique.Methods: In a previously developed setup, DRUG powder was added to a given quantity of the solvent which made some troubles in practical applications. The present work reports another setup which adds solvent to a given mass of the DRUG. The validity of the measured solubilities is checked by comparing the measured solubilities of acetaminophen at two temperatures in water and ethanol mixtures with the corresponding data from the literature.Results: The results reveal that the improved setup could overcome the limitations of the previously developed setup and could be used for DRUG solubility DETERMINATION.Conclusion: The improved setup overcomes the troubles made in the previous setup and could be used in generating large amount of solubility data to be used in the pharmaceutical industry.

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APA: Copy

GHANBARI, AHMAD, SARBAZ, YASHAR, JOUYBAN GHARAMALEKI, VAHID, JOUYBAN GHARAMALEKI, KARIM, SOLEYMANI, JAFAR, & JOUYBAN, ABOLGHASEM. (2016). AN IMPROVED AUTOMATED SETUP FOR SOLUBILITY DETERMINATION OF DRUGS (SHORT COMMUNICATION). PHARMACEUTICAL SCIENCES, 22(3), 210-214. SID. https://sid.ir/paper/703381/en

Vancouver: Copy

GHANBARI AHMAD, SARBAZ YASHAR, JOUYBAN GHARAMALEKI VAHID, JOUYBAN GHARAMALEKI KARIM, SOLEYMANI JAFAR, JOUYBAN ABOLGHASEM. AN IMPROVED AUTOMATED SETUP FOR SOLUBILITY DETERMINATION OF DRUGS (SHORT COMMUNICATION). PHARMACEUTICAL SCIENCES[Internet]. 2016;22(3):210-214. Available from: https://sid.ir/paper/703381/en

IEEE: Copy

AHMAD GHANBARI, YASHAR SARBAZ, VAHID JOUYBAN GHARAMALEKI, KARIM JOUYBAN GHARAMALEKI, JAFAR SOLEYMANI, and ABOLGHASEM JOUYBAN, “AN IMPROVED AUTOMATED SETUP FOR SOLUBILITY DETERMINATION OF DRUGS (SHORT COMMUNICATION),” PHARMACEUTICAL SCIENCES, vol. 22, no. 3, pp. 210–214, 2016, [Online]. Available: https://sid.ir/paper/703381/en

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