THE EFFECT OF ω-FATTY ACIDS ON THE EXPRESSION OF PHOSPHOLIPASE A2 GROUP 2A IN HUMAN GASTRIC CANCER PATIENTS

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SHARIATI MAHBOOBEH; AGHAEI MAHMOUD; MOVAHEDIAN AHMAD; SOMI MOHAMMAD HOSSEIN; DOLATKHAH HOMAYUN; Mirza Aghazade Ahmad

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2016 | Volume:21 | Issue:1 Page(s): 0-0

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Title

THE EFFECT OF ω-FATTY ACIDS ON THE EXPRESSION OF PHOSPHOLIPASE A2 GROUP 2A IN HUMAN GASTRIC CANCER PATIENTS

Author(s)

Keywords

GASTRIC CANCER (GC)

ω-FATTY ACIDS

PHOSPHOLIPASE A2 (PLA2)

Abstract

Background: Studies show that polyunsaturated fatty acids (PUFAs) may have an inhibitory role in carcinogenesis. It was previouslyshown that PLA2 group 2A (PLA2G2A) messenger RNA (mRNA) expression is associated with less frequent metastasis and longersurvival in gastric adenocarcinoma. This study intends to investigate the effect of PUFAs on the expression of PLA2G2A in patientswith gastric cancer. Materials and Methods: Thirty-four patients with gastric cancer (GC) were randomly divided into two groups.The first group received cisplatin medication. The second group received cisplatin medication and supplements of ω-fatty acids forthree courses. The total RNA was extracted from the tissues and cDNA was synthesized. The gene expression of PLA2G2A wasevaluated by the real-time polymerase chain reaction (PCR) method. To confirm the changes in gene expression, frozen sectionwas utilized. The frozen tissue samples were sectioned and stained using the immunohistochemistry technique.Results: Afterchemotherapy and chemotherapy plus supplement, the relative mean of PLA2G2A gene expression increased 1.5 ± 0.5-fold and7.4 ± 2.6-fold, respectively (P=0.006). The relative mean of gene expression in patients who received cisplatin and ω-fatty acidssupplement increased more significantly (7.5 ± 3.3-fold) than in patients who received only cisplatin (P=0.016).Conclusion: It wasfound that PUFAs increased the gene and protein expression of PLA2G2A in gastric cancer. Concerning the fact that studies revealprotective function of PLA2G2A in gastric cancer, it is suggested that increased expression of PLA2G2A is helpful. Furthermore, PUFAs can be considered as a useful therapeutic supplement for patients with gastric cancer.

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APA: Copy

SHARIATI, MAHBOOBEH, AGHAEI, MAHMOUD, MOVAHEDIAN, AHMAD, SOMI, MOHAMMAD HOSSEIN, DOLATKHAH, HOMAYUN, & Mirza Aghazade, Ahmad. (2016). THE EFFECT OF ω-FATTY ACIDS ON THE EXPRESSION OF PHOSPHOLIPASE A2 GROUP 2A IN HUMAN GASTRIC CANCER PATIENTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(1), 0-0. SID. https://sid.ir/paper/703432/en

Vancouver: Copy

SHARIATI MAHBOOBEH, AGHAEI MAHMOUD, MOVAHEDIAN AHMAD, SOMI MOHAMMAD HOSSEIN, DOLATKHAH HOMAYUN, Mirza Aghazade Ahmad. THE EFFECT OF ω-FATTY ACIDS ON THE EXPRESSION OF PHOSPHOLIPASE A2 GROUP 2A IN HUMAN GASTRIC CANCER PATIENTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(1):0-0. Available from: https://sid.ir/paper/703432/en

IEEE: Copy

MAHBOOBEH SHARIATI, MAHMOUD AGHAEI, AHMAD MOVAHEDIAN, MOHAMMAD HOSSEIN SOMI, HOMAYUN DOLATKHAH, and Ahmad Mirza Aghazade, “THE EFFECT OF ω-FATTY ACIDS ON THE EXPRESSION OF PHOSPHOLIPASE A2 GROUP 2A IN HUMAN GASTRIC CANCER PATIENTS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/703432/en

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