APATINIB HAS ANTI-TUMOR EFFECTS AND INDUCES AUTOPHAGY IN COLON CANCER CELLS

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LU WU; KE HE; QIANSHAN DING; ZHEN WANG; XIANG GUOAN; HONGGANG YU

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:9 Page(s): 990-995

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Title

APATINIB HAS ANTI-TUMOR EFFECTS AND INDUCES AUTOPHAGY IN COLON CANCER CELLS

Author(s)

Keywords

APATINIB

APOPTOSIS

AUTOPHAGY

COLON CANCER

MIGRATION

MTOR

Abstract

Objective(s): APATINIB recently has been used to treat patients with gastric cancer, but the function of APATINIB in COLON CANCER remains unclear. This study was conducted to investigate the impacts of APATINIB on the biological function and its potential mechanism of COLON CANCER cells in vitro.Materials and Methods: The effect of APATINIB in COLON CANCER cells were detected by assessing cell viability, MIGRATION and invasion capabilities. APOPTOSIS cells and the cell cycle distribution of COLON CANCER cells were analyzed by flow cytometry. The potential mechanism was investigated via AUTOPHAGY related proteins and pathways in vitro.Results: The proliferation, MIGRATION and invasion of COLON CANCER cells were inhibited when they were treated with different concentration of APATINIB (20, 40 mM). When HCT116 and SW480 cells were treated with APATINIB at the concentration of 20 mM, the APOPTOSIS percentage were 3.7% and 5.8% respectively. As the drug concentration increased to 40mΜ, the the APOPTOSIS percentage increased to 11.9% and 13.5%. Meanwhile, cell cycle was also altered. Furthermore, APATINIB inhibited the expression of AKT-mTOR signaling pathway and increased the expression of LC3-II.Conclusion: APATINIB can significantly inhibit the malignant phenotype of COLON CANCER cells, and it was involved in regulation of AUTOPHAGY.

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APA: Copy

LU, WU, KE, HE, QIANSHAN, DING, ZHEN, WANG, XIANG, GUOAN, & HONGGANG, YU. (2017). APATINIB HAS ANTI-TUMOR EFFECTS AND INDUCES AUTOPHAGY IN COLON CANCER CELLS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(9), 990-995. SID. https://sid.ir/paper/703997/en

Vancouver: Copy

LU WU, KE HE, QIANSHAN DING, ZHEN WANG, XIANG GUOAN, HONGGANG YU. APATINIB HAS ANTI-TUMOR EFFECTS AND INDUCES AUTOPHAGY IN COLON CANCER CELLS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(9):990-995. Available from: https://sid.ir/paper/703997/en

IEEE: Copy

WU LU, HE KE, DING QIANSHAN, WANG ZHEN, GUOAN XIANG, and YU HONGGANG, “APATINIB HAS ANTI-TUMOR EFFECTS AND INDUCES AUTOPHAGY IN COLON CANCER CELLS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 9, pp. 990–995, 2017, [Online]. Available: https://sid.ir/paper/703997/en

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