EFFECTS OF INTRACEREBROVENTRICULAR MICROINJECTION OF HISTAMINE, CHLORPHENIRAMINE AND RANITIDINE ON CONSOLIDATION OF MEMORY IN ADULT MALE RATS

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AHMADI R.; ORYAN SHAHRBANOU; PARIVAR KAZEM; HAERI ROUHANI SEYED ALI

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Journal: JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY) Year:2002 | Volume:11 | Issue:42 Page(s): 3217-3226

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Title

EFFECTS OF INTRACEREBROVENTRICULAR MICROINJECTION OF HISTAMINE, CHLORPHENIRAMINE AND RANITIDINE ON CONSOLIDATION OF MEMORY IN ADULT MALE RATS

Author(s)

AHMADI R. | ORYAN SHAHRBANOU | PARIVAR KAZEM | HAERI ROUHANI SEYED ALI | Issue Writer Certificate

Keywords

MEMORY RETENTIONQ4

H1 AND H2- HISTAMINE RECEPTORSQ4

HISTAMINEQ3

CHLORPHENIRAMINEQ3

RANITIDINEQ3

Abstract

The effect of HISTAMINE on learning and memory is a controversial issue. In this project, the effect of HISTAMINE and it’s antagonists, CHLORPHENIRAMINE and RANITIDINE on MEMORY RETENTION is studied by passive avoidance task and step-through latency (STL) are measured. The results show that HISTAMINE (5, 10, 20 pg/rat) decreases and CHLORPHENIRAMINE (0.1, 1, 10 µg/rat) increases memory rerention in rats. RANITIDINE (0.1, 1, 10, 20 µg/rat) has no effect on this process. The effect of HISTAMINE on MEMORY RETENTION is not blocked by the administration of RANITIDINE. However, administration of CHLORPHENIRAMINE completely counteracted the HISTAMINE effects. Concluding the data analysis demonstration that HISTAMINE act on MEMORY RETENTION by activation of H1- HISTAMINE receptors but not through H2- HISTAMINE receptors.

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APA: Copy

AHMADI, R., ORYAN, SHAHRBANOU, PARIVAR, KAZEM, & HAERI ROUHANI, SEYED ALI. (2002). EFFECTS OF INTRACEREBROVENTRICULAR MICROINJECTION OF HISTAMINE, CHLORPHENIRAMINE AND RANITIDINE ON CONSOLIDATION OF MEMORY IN ADULT MALE RATS. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), 11(42), 3217-3226. SID. https://sid.ir/paper/70414/en

Vancouver: Copy

AHMADI R., ORYAN SHAHRBANOU, PARIVAR KAZEM, HAERI ROUHANI SEYED ALI. EFFECTS OF INTRACEREBROVENTRICULAR MICROINJECTION OF HISTAMINE, CHLORPHENIRAMINE AND RANITIDINE ON CONSOLIDATION OF MEMORY IN ADULT MALE RATS. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)[Internet]. 2002;11(42):3217-3226. Available from: https://sid.ir/paper/70414/en

IEEE: Copy

R. AHMADI, SHAHRBANOU ORYAN, KAZEM PARIVAR, and SEYED ALI HAERI ROUHANI, “EFFECTS OF INTRACEREBROVENTRICULAR MICROINJECTION OF HISTAMINE, CHLORPHENIRAMINE AND RANITIDINE ON CONSOLIDATION OF MEMORY IN ADULT MALE RATS,” JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), vol. 11, no. 42, pp. 3217–3226, 2002, [Online]. Available: https://sid.ir/paper/70414/en

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