Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran

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HAGHIGHI MEHRDAD; HATAMI HOSSEIN; ARYANNEZHAD Shayan; DELBARI NEGAR

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Journal: Infection Epidemiology and Microbiology Year:2021 | Volume:7 | Issue:2 Page(s): 141-154

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Title

Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran

Author(s)

HAGHIGHI MEHRDAD | HATAMI HOSSEIN | ARYANNEZHAD Shayan | DELBARI NEGAR | Issue Writer Certificate

Keywords

SARS-CoV-2

COVID-19

Risk factors

Mortality

Abstract

Backgrounds: Coronavirus disease 2019 (COVID-19) pandemic is considered as a global health challenge, and Iran is among the top ten countries with the highest Mortality rate. This study aimed to analyze epidemiological, clinical, and laboratory features of hospitalized SARS-CoV-2 infected patients and identify the Risk factors of Mortality among them to facilitate the prioritization of resources and vaccine allocation in the population using data available in a large university hospital in Tehran, Iran. Materials & Methods: From February 20 to May 14, 2020, a total of 684 COVID-19 confirmed cases were admitted to Imam Hossein University hospital in Tehran and enrolled in this retrospective observational study. Findings: The mean age of the participants was 59. 48± 16. 65 years, and 55. 8% were male. Compared to survivors, non-survivors (n=127, 18. 57%) were older (69. 09± 14. 16 vs. 57. 29± 16. 40), had higher average number of comorbidities, and more frequently suffered from dyspnea, convulsion, loss of consciousness (LOC), tachycardia, tachypnea, and hypoxia. They also had higher levels of leukocytes, neutrophil count, C-reactive protein (CRP), creatine phosphokinase (CPK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), international normalized ratio (INR), prothrombin time (PT), partial thromboplastin time (PTT), urea, and serum creatinine (p<. 05). Serum potassium (K), lymphocyte count, hemoglobin, HCO3, and serum sodium (Na) were significantly lower in non-survivors. Multivariable logistic regression analysis results revealed that nine variables were positively associated with Mortality. Conclusion: Among COVID-19 patients admitted to the hospital, having more than two or three comorbidities, loss of consciousness, SpO2 < 90%, increased CRP, CPK, urea, and serum potassium, were associated with Mortality.

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APA: Copy

HAGHIGHI, MEHRDAD, HATAMI, HOSSEIN, ARYANNEZHAD, Shayan, & DELBARI, NEGAR. (2021). Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), 7(2), 141-154. SID. https://sid.ir/paper/704436/en

Vancouver: Copy

HAGHIGHI MEHRDAD, HATAMI HOSSEIN, ARYANNEZHAD Shayan, DELBARI NEGAR. Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE)[Internet]. 2021;7(2):141-154. Available from: https://sid.ir/paper/704436/en

IEEE: Copy

MEHRDAD HAGHIGHI, HOSSEIN HATAMI, Shayan ARYANNEZHAD, and NEGAR DELBARI, “Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran,” INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), vol. 7, no. 2, pp. 141–154, 2021, [Online]. Available: https://sid.ir/paper/704436/en

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