DETERMINATION OF AZITHROMYCIN CRYSTALS MORPHOLOGY WILL BE DONE IN SUBSEQUENT CHANGING CONDITIONS AND THE TYPE OF CRYSTALLIZATION PROCESS CHANGE

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RAZZAGHI D.; ATTAR H.; MOLAEI A.; SHOBAYRYAN S.A.

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Journal: JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY) Year:2011 | Volume:21 | Issue:80 (CHEMISTRY ISSUE) Page(s): 1-14

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Title

DETERMINATION OF AZITHROMYCIN CRYSTALS MORPHOLOGY WILL BE DONE IN SUBSEQUENT CHANGING CONDITIONS AND THE TYPE OF CRYSTALLIZATION PROCESS CHANGE

Author(s)

RAZZAGHI D. | ATTAR H. | MOLAEI A. | SHOBAYRYAN S.A. | Issue Writer Certificate

Keywords

AZITHROMYCINQ2

CRYSTALLIZATIONQ2

NANOPARTICLESQ3

CRYSTALS MORPHOLOGYQ2

ULTRASONICQ2

HOMOGENIZERQ2

Abstract

Introduction: The AZITHROMYCIN dehydrate has clinically effective against Gram-positive and Gram-negative bacteria. But the low bioavailability caused to limited its application in clinical and medical cases. According to Noyes-Whitney equation can be increased the drug-loading and dissolution velocity by the reduction of drug particles into the sub-micron range for increasing efficiency of this drug. This will result to low used dosage and improved bioavailability as well as will improve treatment quality eventually.Aim: production of AZITHROMYCIN Dihydrate NANOPARTICLES and determination of AZITHROMYCIN CRYSTALS MORPHOLOGY will be done in subsequent the type of process change.Material and method: Experiments were carried out by following four methods for mixing creation: Magnet and stirrer, ULTRASONIC waves, simple shaking and mixing with HOMOGENIZER.Result: In mixing process with helping HOMOGENIZER in absence of surfactant, acerate crystals AZITHROMYCIN Dihydrate with 290-703 nm diameter was obtained. Conclusion: according to the results of this study by using of mixing with HOMOGENIZER in absence of surfactant and in shorter time period, smaller particles can be attained.

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APA: Copy

RAZZAGHI, D., ATTAR, H., MOLAEI, A., & SHOBAYRYAN, S.A.. (2011). DETERMINATION OF AZITHROMYCIN CRYSTALS MORPHOLOGY WILL BE DONE IN SUBSEQUENT CHANGING CONDITIONS AND THE TYPE OF CRYSTALLIZATION PROCESS CHANGE. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), 21(80 (CHEMISTRY ISSUE)), 1-14. SID. https://sid.ir/paper/70573/en

Vancouver: Copy

RAZZAGHI D., ATTAR H., MOLAEI A., SHOBAYRYAN S.A.. DETERMINATION OF AZITHROMYCIN CRYSTALS MORPHOLOGY WILL BE DONE IN SUBSEQUENT CHANGING CONDITIONS AND THE TYPE OF CRYSTALLIZATION PROCESS CHANGE. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)[Internet]. 2011;21(80 (CHEMISTRY ISSUE)):1-14. Available from: https://sid.ir/paper/70573/en

IEEE: Copy

D. RAZZAGHI, H. ATTAR, A. MOLAEI, and S.A. SHOBAYRYAN, “DETERMINATION OF AZITHROMYCIN CRYSTALS MORPHOLOGY WILL BE DONE IN SUBSEQUENT CHANGING CONDITIONS AND THE TYPE OF CRYSTALLIZATION PROCESS CHANGE,” JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), vol. 21, no. 80 (CHEMISTRY ISSUE), pp. 1–14, 2011, [Online]. Available: https://sid.ir/paper/70573/en

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