Association Between the-1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome

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SAHMANI MEHDI; Dabaghi Ghaleh Talaat; Yargholi Maryam; Forooghi Farshad; JAVADI AMIR; TAHERKHANI Khadijeh

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Journal Paper

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Journal: Journal of Inflammatory Diseases Year:2021 | Volume:24 | Issue:6 (113) Page(s): 486-497

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Title

Association Between the-1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome

Author(s)

Keywords

Polycystic ovary syndrome

TNF-α

Gene polymorphism

Abstract

Background Tumor Necrosis Factor Alpha (TNF-α ) gene, as an inflammatory factor, plays an important role in reproductive physiology, especially in women with Polycystic ovary syndrome (PCOS). Objective This study aims to investigate the relationship between the-1031 T/C polymorphism of TNF-α gene and biochemical factors in women with PCOS. Methods In this case-control study, participants were 106 women with PCOS and 114 healthy women referred to Kosar Hospital in Qazvin, Iran. The TNF-α gene’ s polymorphism was determined using Poly� merase Chain Reaction (PCR) technique and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) method. Biochemical factors of serum levels were also measured in two groups. Logistic regression anal� ysis examined the relationship between the frequency of alleles in different states and the risk of PCOS. Findings There were statistically significant difference in the mean levels of total cholesterol, triglycerides, testosterone, two-hour blood glucose and body mass index between the groups, whose values were higher in women with PCOS compared to healthy women (P<0. 001). In women with PCOS, the mean se� rum levels of triglyceride and high-density lipoprotein were significantly different between the three TT, CC, TC genotypes of TNF-α Gene polymorphism (P<0. 05). The results of regression analysis showed that the TT genotype had significant association with the risk of PCOS (OR=2. 43, P=0. 006, 95%CI: 1. 28-2. 62). Conclusion It seems that there is a relationship between the-1301 (T/C) polymorphism of TNF-α gene and the risk of PCOS in women.

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References

Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics

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APA: Copy

SAHMANI, MEHDI, Dabaghi Ghaleh, Talaat, Yargholi, Maryam, Forooghi, Farshad, JAVADI, AMIR, & TAHERKHANI, Khadijeh. (2021). Association Between the-1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 24(6 (113) ), 486-497. SID. https://sid.ir/paper/706030/en

Vancouver: Copy

SAHMANI MEHDI, Dabaghi Ghaleh Talaat, Yargholi Maryam, Forooghi Farshad, JAVADI AMIR, TAHERKHANI Khadijeh. Association Between the-1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2021;24(6 (113) ):486-497. Available from: https://sid.ir/paper/706030/en

IEEE: Copy

MEHDI SAHMANI, Talaat Dabaghi Ghaleh, Maryam Yargholi, Farshad Forooghi, AMIR JAVADI, and Khadijeh TAHERKHANI, “Association Between the-1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 24, no. 6 (113) , pp. 486–497, 2021, [Online]. Available: https://sid.ir/paper/706030/en

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