مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

417
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

114
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

TARGETOME ANALYSIS REVEALED INVOLVEMENT OF MIR-126 IN NEUROTROPHIN SIGNALING PATHWAY: A POSSIBLE ROLE IN PREVENTION OF GLIOMA DEVELOPMENT

Pages

  150-156

Abstract

 Objective: For the first time, we used molecular signaling pathway enrichment analysis to determine possible involvement of MIR-126 and IRS-1 in NEUROTROPHIN pathway.Materials and Methods: In this prospective study, validated and predicted targets (targetome) of MIR-126 were collected following searching miRtarbase (http://mirtarbase.mbc.nctu.edu.tw/) and miRWalk 2.0 databases, respectively. Then, approximate expression of MIR-126 targeting in GLIOMA tissue was examined using UniGene database (http://www.ncbi. nlm.nih.gov/unigene). In silico molecular pathway enrichment analysis was carried out by DAVID 6.7 database (http://david. abcc.ncifcrf.gov/) to explore which signaling pathway is related to MIR-126 targeting and how MIR-126 attributes to GLIOMA development.Results: MIR-126 exerts a variety of functions in cancer pathogenesis via suppression of expression of target gene including PI3K, KRAS, EGFL7, IRS-1 and VEGF. Our bioinformatic studies implementing DAVID database, showed the involvement of MIR-126 target genes in several signaling pathways including cancer pathogenesis, NEUROTROPHIN functions, GLIOMA formation, insulin function, focal adhesion production, chemokine synthesis and secretion and regulation of the actin cytoskeleton.Conclusion: Taken together, we concluded that MIR-126 enhances the formation of GLIOMA cancer stem cell probably via down regulation of IRS-1 in NEUROTROPHIN signaling pathway.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Rouigari, Maedeh, DEHBASHI, MOEIN, GHAEDI, KAMRAN, & POURHOSSEIN, MERAJ. (2018). TARGETOME ANALYSIS REVEALED INVOLVEMENT OF MIR-126 IN NEUROTROPHIN SIGNALING PATHWAY: A POSSIBLE ROLE IN PREVENTION OF GLIOMA DEVELOPMENT. CELL JOURNAL (YAKHTEH), 20(2), 150-156. SID. https://sid.ir/paper/706493/en

    Vancouver: Copy

    Rouigari Maedeh, DEHBASHI MOEIN, GHAEDI KAMRAN, POURHOSSEIN MERAJ. TARGETOME ANALYSIS REVEALED INVOLVEMENT OF MIR-126 IN NEUROTROPHIN SIGNALING PATHWAY: A POSSIBLE ROLE IN PREVENTION OF GLIOMA DEVELOPMENT. CELL JOURNAL (YAKHTEH)[Internet]. 2018;20(2):150-156. Available from: https://sid.ir/paper/706493/en

    IEEE: Copy

    Maedeh Rouigari, MOEIN DEHBASHI, KAMRAN GHAEDI, and MERAJ POURHOSSEIN, “TARGETOME ANALYSIS REVEALED INVOLVEMENT OF MIR-126 IN NEUROTROPHIN SIGNALING PATHWAY: A POSSIBLE ROLE IN PREVENTION OF GLIOMA DEVELOPMENT,” CELL JOURNAL (YAKHTEH), vol. 20, no. 2, pp. 150–156, 2018, [Online]. Available: https://sid.ir/paper/706493/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button