TROPHIC EFFECTS OF VANADIUM ON BETA – CELLS OF STZ-INDUCED INSULIN DEPENDENT DIADETIC RATS & EVIDENCE FOR LONG TERM DIABETES MELLITUS

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DEHGHAN G.A.; SOTOODEN M.; OMRANI GH.R.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2001 | Volume:1 | Issue:1 Page(s): 1-8

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Title

TROPHIC EFFECTS OF VANADIUM ON BETA – CELLS OF STZ-INDUCED INSULIN DEPENDENT DIADETIC RATS & EVIDENCE FOR LONG TERM DIABETES MELLITUS

Author(s)

DEHGHAN G.A. | SOTOODEN M. | OMRANI GH.R. | Issue Writer Certificate

Keywords

CARIES FERRQ2

TOOTH CARIESQ4

RAFSANJANQ4

STUDENTQ2

Abstract

Background: The effects of one year combined vanadium and insulin treatment (VIT ) on blood glucose levels of insulin dependent diabetic (IDD) rats were studied. Materials and Methods: Rats made diabetic by an iv injection of 55-60 mg/kg streptozotocin (STZ), divided into two groups and treated with a low dose of NPH insulin (2-4 U/rat) for two months to survive from hyperglycemic shock. In group A, hyperglycaemia during one year by increasing the daily dose of insulin to 8.2+0.4 U/100g (IT) and in group B by switching over to hydrated vanadium solution (1 mg/kg vanady 1 oxide sulphate pent hydrate in drinking water; VIT). Results: the results of the study indicated that one yare VIT regenerated new beta–cells, and relieved diabetes both during treatment and after withdrawal. Howeve, one year IT showed no trophic effects on the destroyed beta- cells hence no improvement in the glycaemic status of the animal was seen after withdrawal. The action of VIT was such that in group B normoglycaemeia persisted in 90 percent of diabetic rats two weeks after insulin withdrawal. But in the same group, 45 days after combied vanadium and insulin withdrawal blood glucosc was normal in 60 per cent of the rats, it was between 250 –300 mg/dl in 18 per cent and between 350- 400 mg/dl in 24 per cent of the rats. Conclusion: It appears that long term VIT regenerates pancreatic beta-cells of IDD rats and possibly by improving their secretary functions it relieves diabetes mellitus.

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APA: Copy

DEHGHAN, G.A., SOTOODEN, M., & OMRANI, GH.R.. (2001). TROPHIC EFFECTS OF VANADIUM ON BETA – CELLS OF STZ-INDUCED INSULIN DEPENDENT DIADETIC RATS & EVIDENCE FOR LONG TERM DIABETES MELLITUS . JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 1(1), 1-8. SID. https://sid.ir/paper/70825/en

Vancouver: Copy

DEHGHAN G.A., SOTOODEN M., OMRANI GH.R.. TROPHIC EFFECTS OF VANADIUM ON BETA – CELLS OF STZ-INDUCED INSULIN DEPENDENT DIADETIC RATS & EVIDENCE FOR LONG TERM DIABETES MELLITUS . JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2001;1(1):1-8. Available from: https://sid.ir/paper/70825/en

IEEE: Copy

G.A. DEHGHAN, M. SOTOODEN, and GH.R. OMRANI, “TROPHIC EFFECTS OF VANADIUM ON BETA – CELLS OF STZ-INDUCED INSULIN DEPENDENT DIADETIC RATS & EVIDENCE FOR LONG TERM DIABETES MELLITUS ,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 1, no. 1, pp. 1–8, 2001, [Online]. Available: https://sid.ir/paper/70825/en

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