COMPARATIVE STUDIES OF EXTRACTION CHROMATOGRAPHY AND ELECTROAMALGAMATION SEPARATION TO PRODUCE NO-CARRIER ADDED 177LU BY TEHRAN RESEARCH REACTOR

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SALEK NAFISE; SHAMSAEI MOJTABA; GHANNADI MARAGHEH MOHAMMAD; SHIRVANI ARANI SIMINDOKHT; BAHRAMI SAMANI ALI

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Journal: Iranian Journal of Nuclear Medicine Year:2017 | Volume:25 | Issue:1 (SERIAL NUMBER 47) Page(s): 23-33

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Title

COMPARATIVE STUDIES OF EXTRACTION CHROMATOGRAPHY AND ELECTROAMALGAMATION SEPARATION TO PRODUCE NO-CARRIER ADDED 177LU BY TEHRAN RESEARCH REACTOR

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Keywords

177LU

NO CARRIER ADDED

EXTRACTION CHROMATOGRAPHY SEPARATION

ELECTRO-AMALGAMATION SEPARATION

Abstract

Introduction: Owing to its favorable radionuclidic characteristics, such as tl/2=6.73 day and Eb (max) =497 keV and ease of its large-scale production using medium flux research reactors, lutetium-177 (177Lu) is an attractive radionuclide for various therapeutic applications. NO CARRIER ADDED (NCA) 177Lu was obtained by thermal neutron bombardment (4×1013 n/cm2.s) of 176Yb target through 176Yb (n, g) 177Yb ® 177Lu process have the advantage of preparing radiopharmaceuticals with high specific activity.So the existence of an effective Lu/Yb separation method is critical.Methods: Many researchers illustrated no-carrier added 177Lu production. However, the present study is based on comparison between two potential separation methods, namely extraction chromatography and ELECTRO-AMALGAMATION SEPARATION with respect to separation yield and radiochemical characteristics.Results: The NO CARRIER ADDED 177Lu separated from 176Yb target by two extraction chromatography and ELECTRO-AMALGAMATION SEPARATION methods. The effective parameters on separation Lu/Yb were investigated in two procedures. The 177Lu production yield by extraction chromatography and electro-amalgamation procedures were 82% and 88.83% respectively. The NO CARRIER ADDED 177Lu was obtained with radionuclidic purity of 99.99% in two separation methods.Conclusion: Although both separation methods have exhibited promising feature, the study reveals that ELECTRO-AMALGAMATION SEPARATION offers the advantages of higher yield of 177Lu, simplicity and easier to operate for large amount of target and less overall processing time.

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APA: Copy

SALEK, NAFISE, SHAMSAEI, MOJTABA, GHANNADI MARAGHEH, MOHAMMAD, SHIRVANI ARANI, SIMINDOKHT, & BAHRAMI SAMANI, ALI. (2017). COMPARATIVE STUDIES OF EXTRACTION CHROMATOGRAPHY AND ELECTROAMALGAMATION SEPARATION TO PRODUCE NO-CARRIER ADDED ¹⁷⁷LU BY TEHRAN RESEARCH REACTOR. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 25(1 (SERIAL NUMBER 47)), 23-33. SID. https://sid.ir/paper/708469/en

Vancouver: Copy

SALEK NAFISE, SHAMSAEI MOJTABA, GHANNADI MARAGHEH MOHAMMAD, SHIRVANI ARANI SIMINDOKHT, BAHRAMI SAMANI ALI. COMPARATIVE STUDIES OF EXTRACTION CHROMATOGRAPHY AND ELECTROAMALGAMATION SEPARATION TO PRODUCE NO-CARRIER ADDED ¹⁷⁷LU BY TEHRAN RESEARCH REACTOR. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2017;25(1 (SERIAL NUMBER 47)):23-33. Available from: https://sid.ir/paper/708469/en

IEEE: Copy

NAFISE SALEK, MOJTABA SHAMSAEI, MOHAMMAD GHANNADI MARAGHEH, SIMINDOKHT SHIRVANI ARANI, and ALI BAHRAMI SAMANI, “COMPARATIVE STUDIES OF EXTRACTION CHROMATOGRAPHY AND ELECTROAMALGAMATION SEPARATION TO PRODUCE NO-CARRIER ADDED ¹⁷⁷LU BY TEHRAN RESEARCH REACTOR,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 1 (SERIAL NUMBER 47), pp. 23–33, 2017, [Online]. Available: https://sid.ir/paper/708469/en

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