DOWNREGULATION OF EXTRACELLULAR MATRIX AND CELL ADHESION MOLECULES IN CUMULUS CELLS OF INFERTILE POLYCYSTIC OVARY SYNDROME WOMEN WITH AND WITHOUT INSULIN RESISTANCE

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HASSANI FATEMEH; ORYAN SHAHRBANOO; EFTEKHARI YAZDI POOPAK; BAZRGAR MASOUD; MOINI ASHRAF; NASIRI NAHID; SHARIFI ZARCHI ALI

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Journal: Cell Journal (Yakhteh) Year:2019 | Volume:21 | Issue:1 Page(s): 35-42

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Title

DOWNREGULATION OF EXTRACELLULAR MATRIX AND CELL ADHESION MOLECULES IN CUMULUS CELLS OF INFERTILE POLYCYSTIC OVARY SYNDROME WOMEN WITH AND WITHOUT INSULIN RESISTANCE

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Keywords

CUMULUS CELLS

EXTRACELLULAR MATRIX

GENE EXPRESSION

INSULIN RESISTANCE

POLYCYSTIC OVARY SYNDROME

Abstract

Objective: The EXTRACELLULAR MATRIX (ECM) of the cumulus oocyte complex (COC) is composed of several molecules that have different roles during follicle development. This study aims to explore GENE EXPRESSION profiles for ECM and cell adhesion molecules in the CUMULUS CELLS of POLYCYSTIC OVARY SYNDROME (PCOS) patients based on their insulin sensitivity following controlled ovarian stimulation (COS).Materials and Methods: In this prospective case-control study enrolled 23 women less than 36 years of age who participated in an intracytoplasmic sperm injection (ICSI) program. Patients were subdivided into 3 groups: control (n=8, fertile women with male infertility history), insulin resistant (IR) PCOS (n=7), and insulin sensitive (IS) PCOS (n=8). We compared 84 ECM component and adhesion molecule GENE EXPRESSIONs by quantitative real-time polymerase chain reaction array (qPCR-array) among the groups.Results: We noted that 21 of the 84 studied genes differentially expressed among the groups, from which 18 of these genes down regulated. Overall, comparison of PCOS cases with controls showed down regulation of EXTRACELLULAR MATRIX protein 1 (ECM1); catenin (cadherin-associated protein), alpha 1 (CTNNA1); integrin, alpha 5 (ITGA5); laminin, alpha 3 (LAMA3); laminin, beta 1 (LAMB1); fibronectin 1 (FN1); and integrin, alpha 7 (ITGA7). In the IS group, there was upregulation of ADAM metallopeptidase with thrombospondin type 1 motif, 8 (ADAMTS8) and neural cell adhesion molecule 1 (NCAM1) compared with the controls (P<0.05).Conclusion: Down regulation of ECM and cell adhesion molecules seem to be related to PCOS. GENE EXPRESSION profile alterations in CUMULUS CELLS from both the IS and IR groups of PCOS patients seems to be involved in the composition and regulation of ECM during the ovulation process. This study highlights the association of ECM gene alteration as a viewpoint for additional understanding of the etiology of PCOS.

Cites

A Histomorphological Comparative Effects of Metformin, Pioglitazone, Repaglinide and Acarbose on Polycystic Ovary in Mice

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APA: Copy

HASSANI, FATEMEH, ORYAN, SHAHRBANOO, EFTEKHARI YAZDI, POOPAK, BAZRGAR, MASOUD, MOINI, ASHRAF, NASIRI, NAHID, & SHARIFI ZARCHI, ALI. (2019). DOWNREGULATION OF EXTRACELLULAR MATRIX AND CELL ADHESION MOLECULES IN CUMULUS CELLS OF INFERTILE POLYCYSTIC OVARY SYNDROME WOMEN WITH AND WITHOUT INSULIN RESISTANCE. CELL JOURNAL (YAKHTEH), 21(1), 35-42. SID. https://sid.ir/paper/708485/en

Vancouver: Copy

HASSANI FATEMEH, ORYAN SHAHRBANOO, EFTEKHARI YAZDI POOPAK, BAZRGAR MASOUD, MOINI ASHRAF, NASIRI NAHID, SHARIFI ZARCHI ALI. DOWNREGULATION OF EXTRACELLULAR MATRIX AND CELL ADHESION MOLECULES IN CUMULUS CELLS OF INFERTILE POLYCYSTIC OVARY SYNDROME WOMEN WITH AND WITHOUT INSULIN RESISTANCE. CELL JOURNAL (YAKHTEH)[Internet]. 2019;21(1):35-42. Available from: https://sid.ir/paper/708485/en

IEEE: Copy

FATEMEH HASSANI, SHAHRBANOO ORYAN, POOPAK EFTEKHARI YAZDI, MASOUD BAZRGAR, ASHRAF MOINI, NAHID NASIRI, and ALI SHARIFI ZARCHI, “DOWNREGULATION OF EXTRACELLULAR MATRIX AND CELL ADHESION MOLECULES IN CUMULUS CELLS OF INFERTILE POLYCYSTIC OVARY SYNDROME WOMEN WITH AND WITHOUT INSULIN RESISTANCE,” CELL JOURNAL (YAKHTEH), vol. 21, no. 1, pp. 35–42, 2019, [Online]. Available: https://sid.ir/paper/708485/en

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