ASSOCIATION OF ANRIL EXPRESSION WITH CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS

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Rahimi Esmaeil; AHMADI AMIRHOSSEIN; BOROUMAND MOHAMMAD ALI; MOHAMMAD SOLTANI BAHRAM; BEHMANESH MEHRDAD

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Journal Paper

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Journal: Cell Journal (Yakhteh) Year:2018 | Volume:20 | Issue:1 Page(s): 41-45

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Title

ASSOCIATION OF ANRIL EXPRESSION WITH CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS

Author(s)

Keywords

ANRIL

CORONARY ARTERY DISEASE

GENE EXPRESSION

NONCODING RNA

TYPE 2 DIABETES MELLITUS

Abstract

Objective: ANRIL is an important antisense NONCODING RNA gene in the INK4 locus (9p21.3), a hot spot region associated with multiple disorders including CORONARY ARTERY DISEASE (CAD), TYPE 2 DIABETES MELLITUS (T2DM) and many different types of cancer. It has been shown that its expression is dysregulated in a variety of immune-mediated diseases. CAD is a major problem in T2DM patients and the cause of almost 60% of deaths in these patients worldwide. The aim of the present study was to compare the expression level of ANRIL between T2DM patients with and without CAD.Materials and Methods: In this case-control study, we examined ANRIL expression in peripheral blood mononuclear cell samples by quantitative reverse transcription- polymerase chain reaction (RT-qPCR) in 64 T2DM patients with and without CAD (33 CAD+and 31 CAD- patients respectively, established by coronary angiography).Results: Expression analysis revealed that ANRIL was up regulated (2.34-Fold, P=0.012) in CAD+versus CAD diabetic patients. Data from receiver operating characteristic (ROC) curve analysis has shown that ANRIL could act as a potential biomarker for detecting CAD in diabetic patients.Conclusion: The expression level of ANRIL is associated with presence of CAD in diabetic patients and could be considered as a potential peripheral biomarker.

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APA: Copy

Rahimi, Esmaeil, AHMADI, AMIRHOSSEIN, BOROUMAND, MOHAMMAD ALI, MOHAMMAD SOLTANI, BAHRAM, & BEHMANESH, MEHRDAD. (2018). ASSOCIATION OF ANRIL EXPRESSION WITH CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS. CELL JOURNAL (YAKHTEH), 20(1), 41-45. SID. https://sid.ir/paper/708552/en

Vancouver: Copy

Rahimi Esmaeil, AHMADI AMIRHOSSEIN, BOROUMAND MOHAMMAD ALI, MOHAMMAD SOLTANI BAHRAM, BEHMANESH MEHRDAD. ASSOCIATION OF ANRIL EXPRESSION WITH CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS. CELL JOURNAL (YAKHTEH)[Internet]. 2018;20(1):41-45. Available from: https://sid.ir/paper/708552/en

IEEE: Copy

Esmaeil Rahimi, AMIRHOSSEIN AHMADI, MOHAMMAD ALI BOROUMAND, BAHRAM MOHAMMAD SOLTANI, and MEHRDAD BEHMANESH, “ASSOCIATION OF ANRIL EXPRESSION WITH CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS,” CELL JOURNAL (YAKHTEH), vol. 20, no. 1, pp. 41–45, 2018, [Online]. Available: https://sid.ir/paper/708552/en

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