SEMAPHORIN-3A AS AN IMMUNE MODULATOR IS SUPPRESSED BY MICRORNA-145-5P

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

REZAEEPOOR MAHSA; GANJALIKHANI HAKEMI MAZDAK; SHAPOORI SHIMA; ESKANDARI NAHID; SHARIFI MOHAMMADREZA; ETEMADIFAR MASOUD; MANSUORIAN MARJAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2018 | Volume:20 | Issue:1 Page(s): 113-119

Download Full-Text

View:

245

Download:

Cites:

Information Journal Paper

Title

SEMAPHORIN-3A AS AN IMMUNE MODULATOR IS SUPPRESSED BY MICRORNA-145-5P

Author(s)

Keywords

MICRORNAS

MIR-145-5P

SEMAPHORIN-3A

Abstract

Objective: SEMAPHORIN-3A (SEMA3A) and its receptors are found on some immune cells and act as suppressors of immune cells over-activation. Considering the role ofSEMA3A and its down-regulation in some autoimmune diseases, as well as our bioinformatics predictions, we assumed that MIR-145-5P might affect SEMA3A expression. So, we aimed to determine the effect of MIR-145-5P onSEMA3A gene expression level.Materials and Methods: In this experimental study, we evaluated the effect of MIR-145-5P transfection on SEMA3A expression in peripheral blood mononuclear cells (PBMCs) using ELISA and quantitative real-time polymerase chain reaction (PCR) methods.Results: Our results showed that MIR-145-5P is able to decrease SEMA3A expression at both protein and mRNA levels. These data confirmed our previous bioinformatic prediction about the inhibitory effect of MIR-145-5P on SEMA3A expression.Conclusion: These results enlightened us about an unknown aspect of SEMA3A role in some autoimmune disorders like multiple sclerosis (MS) and rheumatoid arthritis (RA) and also proposedSEMA3A as a potential therapeutic approach.

Cites

No record.

References

No record.

Cite

APA: Copy

REZAEEPOOR, MAHSA, GANJALIKHANI HAKEMI, MAZDAK, SHAPOORI, SHIMA, ESKANDARI, NAHID, SHARIFI, MOHAMMADREZA, ETEMADIFAR, MASOUD, & MANSUORIAN, MARJAN. (2018). SEMAPHORIN-3A AS AN IMMUNE MODULATOR IS SUPPRESSED BY MICRORNA-145-5P. CELL JOURNAL (YAKHTEH), 20(1), 113-119. SID. https://sid.ir/paper/708560/en

Vancouver: Copy

REZAEEPOOR MAHSA, GANJALIKHANI HAKEMI MAZDAK, SHAPOORI SHIMA, ESKANDARI NAHID, SHARIFI MOHAMMADREZA, ETEMADIFAR MASOUD, MANSUORIAN MARJAN. SEMAPHORIN-3A AS AN IMMUNE MODULATOR IS SUPPRESSED BY MICRORNA-145-5P. CELL JOURNAL (YAKHTEH)[Internet]. 2018;20(1):113-119. Available from: https://sid.ir/paper/708560/en

IEEE: Copy

MAHSA REZAEEPOOR, MAZDAK GANJALIKHANI HAKEMI, SHIMA SHAPOORI, NAHID ESKANDARI, MOHAMMADREZA SHARIFI, MASOUD ETEMADIFAR, and MARJAN MANSUORIAN, “SEMAPHORIN-3A AS AN IMMUNE MODULATOR IS SUPPRESSED BY MICRORNA-145-5P,” CELL JOURNAL (YAKHTEH), vol. 20, no. 1, pp. 113–119, 2018, [Online]. Available: https://sid.ir/paper/708560/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops