INVESTIGATION ON GENE-ENVIRONMENT INTERACTION USING BREAST CANCER DATA; A CASE-ONLY AND CASE-CONTROL DESIGNS

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MORADZADEH R.; HASANZADEH J.; RAJAAEIFARD A.R.; TAHMASEBI S.; GOLMOHAMMADI P.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2012 | Volume:10 | Issue:4 (41) Page(s): 267-278

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Title

INVESTIGATION ON GENE-ENVIRONMENT INTERACTION USING BREAST CANCER DATA; A CASE-ONLY AND CASE-CONTROL DESIGNS

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Keywords

CASE-ONLYQ2

CASE-CONTROLQ2

BREAST CANCERQ2

GENE-ENVIRONMENT INTERACTIONQ2

Abstract

Background and Objectives: The role of GENE-ENVIRONMENT INTERACTION in epidemiology has been widely considered. The traditional methods of studying the GENE-ENVIRONMENT INTERACTION need appropriate control groups which their selection may be associated with some problems. Therefore, new methods have been created to study these interactions from which are the CASE-ONLY designs. In this method, only the cases data are being used. In this study, GENE-ENVIRONMENT INTERACTION in patients with BREAST CANCER was investigated using the CASE-ONLY and CASE-CONTROL designs.Material and Methods: This study conducted in 2008, using two methods: matched CASE-CONTROL and CASE-ONLY. Simple random sampling was used to select 300 patients with BREAST CANCER in Shahid Mottahari Clinic for two aforementhioned designs. The control group for the matched CASE-CONTROL study was selected from the women referring to Shahid Mottahari Clinic. Data were analysed using lagistic regressian and conditional logistic regression.Results: The confidence intervals and log likelihood in all variables in CASE-ONLY design was better than the matched CASE-CONTROL. In CASE-ONLY design, the standard error in the following variables; age at menarche, the first delivery at the age of ³34yrs and/or nulliparity, the number of live births, use of oral contraception pills, and breastfeeding history were less than those in the matched CASE-CONTROL design. In CASE-ONLY design, the P-value of the above-menthined variables was less than those of the matched CASE-CONTROL design.Conclusion: The CASE-ONLY design is an efficiency method for investigating of the interaction in terms of statistical study, sample size and the easily implementing.

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APA: Copy

MORADZADEH, R., HASANZADEH, J., RAJAAEIFARD, A.R., TAHMASEBI, S., & GOLMOHAMMADI, P.. (2012). INVESTIGATION ON GENE-ENVIRONMENT INTERACTION USING BREAST CANCER DATA; A CASE-ONLY AND CASE-CONTROL DESIGNS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 10(4 (41)), 267-278. SID. https://sid.ir/paper/70872/en

Vancouver: Copy

MORADZADEH R., HASANZADEH J., RAJAAEIFARD A.R., TAHMASEBI S., GOLMOHAMMADI P.. INVESTIGATION ON GENE-ENVIRONMENT INTERACTION USING BREAST CANCER DATA; A CASE-ONLY AND CASE-CONTROL DESIGNS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2012;10(4 (41)):267-278. Available from: https://sid.ir/paper/70872/en

IEEE: Copy

R. MORADZADEH, J. HASANZADEH, A.R. RAJAAEIFARD, S. TAHMASEBI, and P. GOLMOHAMMADI, “INVESTIGATION ON GENE-ENVIRONMENT INTERACTION USING BREAST CANCER DATA; A CASE-ONLY AND CASE-CONTROL DESIGNS,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 10, no. 4 (41), pp. 267–278, 2012, [Online]. Available: https://sid.ir/paper/70872/en

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