THE EFFECT OF ZINC SUPPLEMENTATION ON TREATMENT OF ACUTE WATERY DIARRHEA IN 1-4 YEAR OLD CHILDREN

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NOURI SHADKAM M.; MOZAFARI KHOSRAVI H.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2007 | Volume:5 | Issue:4 (21) Page(s): 247-252

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Title

THE EFFECT OF ZINC SUPPLEMENTATION ON TREATMENT OF ACUTE WATERY DIARRHEA IN 1-4 YEAR OLD CHILDREN

Author(s)

NOURI SHADKAM M. | MOZAFARI KHOSRAVI H. | Issue Writer Certificate

Keywords

ACUTE WATERY DIARRHEAQ3

ZINC SUPPLEMENTATIONQ2

TREATMENT OF DIARRHEAQ3

Abstract

Background and Objective: Patients with diarrhea are susceptible to zinc deficiency. Zinc deficiency can cause growth retardation, delay in sexual maturity, behavior disorders, persistent diarrhea and abnormalities of immune system, susceptibility to respiratory and gastrointestinal infections and impairment of taste and smell perception. The aim of this study was to evaluate of the effect of oral ZINC SUPPLEMENTATION on the treatment of ACUTE WATERY DIARRHEA.Materials and Methods: This study was a randomized double-blind placebo controlled clinical trial that was carried out in 139 children, aged 1 to 4 years, with ACUTE WATERY DIARRHEA referred to two out-patient pediatric clinics in Yazd. Participants were randomly divided into two groups, zinc group (ZG) and placebo group (PG). The former group received zinc sulphate 2 mg/kg qd orally for 10 days and the latter group were treated with saline-dextrose solution (1/3:2/3). Duration and frequency of the diarrhea episodes were recorded in each group. Data were analyzed using Chi-square and Student Hest.Results: The mean frequency of diarrhea at the first visit in ZG and PG groups were 4.6±1.7 and 4.2±1.5, respectively (p=0.1). At forty-eight to 72 h post-intervention, these values were 2.32±1.43 and 3.84±1.34 for girls (p=0.001), and 2.21±1.49 and 3.9±1.8 (p=0.001), for boys respectively. In general, after five days intervention, 45 patients (43%) were recovered, that 24 (53%) of them were from ZG. However, 10 days after the intervention the recovery rate in the ZG was markedly higher than the control group. At the end of the intervention, 80 (77%) patients, with 50 cases (66%) belonging to the ZG completely recovered.Conclusion: This study showed that oral ZINC SUPPLEMENTATION (2mg/kg qd) in children with ACUTE WATERY DIARRHEA. reduces the duration and severity of diarrhea.

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APA: Copy

NOURI SHADKAM, M., & MOZAFARI KHOSRAVI, H.. (2007). THE EFFECT OF ZINC SUPPLEMENTATION ON TREATMENT OF ACUTE WATERY DIARRHEA IN 1-4 YEAR OLD CHILDREN. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 5(4 (21)), 247-252. SID. https://sid.ir/paper/70881/en

Vancouver: Copy

NOURI SHADKAM M., MOZAFARI KHOSRAVI H.. THE EFFECT OF ZINC SUPPLEMENTATION ON TREATMENT OF ACUTE WATERY DIARRHEA IN 1-4 YEAR OLD CHILDREN. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2007;5(4 (21)):247-252. Available from: https://sid.ir/paper/70881/en

IEEE: Copy

M. NOURI SHADKAM, and H. MOZAFARI KHOSRAVI, “THE EFFECT OF ZINC SUPPLEMENTATION ON TREATMENT OF ACUTE WATERY DIARRHEA IN 1-4 YEAR OLD CHILDREN,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 5, no. 4 (21), pp. 247–252, 2007, [Online]. Available: https://sid.ir/paper/70881/en

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