THE EFFECT OF ANTINOCICEPTIVE AND ANTI INFLAMMATORY OF HYDRO –ALCOHOL EXTRACT OF DOREMA AUCHERI ON FORMALIN TEST AND CARRAGEENAN MODEL IN RAT

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MOKHTARI MOKHTAR; SHARIATI MEHRDAD; NIKNAM H.

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Paper Information

Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2008 | Volume:7 | Issue:3 (28) Page(s): 165-172

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Title

THE EFFECT OF ANTINOCICEPTIVE AND ANTI INFLAMMATORY OF HYDRO –ALCOHOL EXTRACT OF DOREMA AUCHERI ON FORMALIN TEST AND CARRAGEENAN MODEL IN RAT

Author(s)

MOKHTARI MOKHTAR | SHARIATI MEHRDAD | NIKNAM H. | Issue Writer Certificate

Keywords

PAINQ2

INFLAMMATIONQ2

DOREMA AUCHERIQ3

RATQ2

Abstract

Background and Objectives: Considering the importance of extracts of Umbelliferae herbs, the present study aimed to investigate the antinociceptive and anti- inflammatory effects of hydro alcoholic extract of DOREMA AUCHERI.Material and Methods: In this experimental study, the experiments were performed on 80 male wistar RATs weighting 190 to 200 grams, which were divided into 10 groups, each consisting of 8 RATs.To evaluate the antinociceptive effects, the formalin induced PAIN-test was used and for assessing anti- inflammatory effects, the carrageenan induced hind paw edema model in RATs was used. All animals were pre-treated with an oral dose of extracts (100, 200, 400 mg/kg). The control group received no drug and the sham group at only received distilled water. The first 0-5 min and 16-60 min after formalin injection were considered as acute and chronic phases, respectively. The paw volume measured in the mercury from 0 to 2 h and 30 min after carrageenan injection. Statistical analysis of the data was performed using ANOVA and t-test where appropriate.Results: Results of this study showed that extracts of Diorama archery can significantly reduce the PAIN depending on the dose in acute phase (p<0.05). However, in chronic phase, the high dose of the extract could reduce the PAIN. These results also revealed that the highest dose of extract can reduce paw edema in carrageenan test.Conclusions: It seems that flavonoids can probably reduce intracellular calcium through inhibiting of NMDA receptors. It also reduces activities of nitric oxide synthase enzyme and calcium dependent phospholipids A2, which results in antinociceptive effects. It may also be concluded that the anti-inflammatory effects of the extracts are through reduction of prostaglandins. Considering the above findings, Diorama archery as an antinociceptive and anti-inflammatory medicine could be introduced.

Cites

ASSESSMENT OF PHYTOCHEMICAL, MORPHOLOGICAL AND ANTIOXIDANT VARIATION OF BILEHAR (DOREMA AUCHERI) POPULATIONS CULTIVATED IN DIFFERENT ENVIRONMENTAL CONDITIONS

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APA: Copy

MOKHTARI, MOKHTAR, SHARIATI, MEHRDAD, & NIKNAM, H.. (2008). THE EFFECT OF ANTINOCICEPTIVE AND ANTI INFLAMMATORY OF HYDRO –ALCOHOL EXTRACT OF DOREMA AUCHERI ON FORMALIN TEST AND CARRAGEENAN MODEL IN RAT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 7(3 (28)), 165-172. SID. https://sid.ir/paper/70893/en

Vancouver: Copy

MOKHTARI MOKHTAR, SHARIATI MEHRDAD, NIKNAM H.. THE EFFECT OF ANTINOCICEPTIVE AND ANTI INFLAMMATORY OF HYDRO –ALCOHOL EXTRACT OF DOREMA AUCHERI ON FORMALIN TEST AND CARRAGEENAN MODEL IN RAT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2008;7(3 (28)):165-172. Available from: https://sid.ir/paper/70893/en

IEEE: Copy

MOKHTAR MOKHTARI, MEHRDAD SHARIATI, and H. NIKNAM, “THE EFFECT OF ANTINOCICEPTIVE AND ANTI INFLAMMATORY OF HYDRO –ALCOHOL EXTRACT OF DOREMA AUCHERI ON FORMALIN TEST AND CARRAGEENAN MODEL IN RAT,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 7, no. 3 (28), pp. 165–172, 2008, [Online]. Available: https://sid.ir/paper/70893/en

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