NICORANDIL EFFECT ON MYOCARDIAL PERFUSION IN PATIENTS WITH SLOW CORONARY FLOW PHENOMENON ASSESSMENT BY GATED MYOCARDIAL PERFUSION SPECT

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DABBAGH KAKHKI VAHID REZA; ESHRAGHI ALI; AYATI NARJESS; VOJDANPARAST MOHAMMAD; SADEGHI RAMIN; REZVANI KHORASHAD AZADEH

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Journal: Iranian Journal of Nuclear Medicine Year:2017 | Volume:25 | Issue:1 (SERIAL NUMBER 47) Page(s): 60-65

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Title

NICORANDIL EFFECT ON MYOCARDIAL PERFUSION IN PATIENTS WITH SLOW CORONARY FLOW PHENOMENON ASSESSMENT BY GATED MYOCARDIAL PERFUSION SPECT

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Keywords

ANGINA

NICORANDIL

GATED SPECT

MYOCARDIAL PERFUSION

Abstract

Introduction: Patients with the coronary slow flow phenomenon (SCF) frequently experience ANGINA episodes. The purpose of this study was to determine efficacy of NICORANDIL in MYOCARDIAL PERFUSION in patients with SCF.Methods: Twenty patients (50.85 ± 12.96 y) with SCF were studied. We evaluate coronary slow flow according to protracted thrombolysis in myocardial infarction (TIMI) frame count. After diagnosis of SCF, all patients underwent dipyridamole stress/rest gated 99mTc-sestamibi SPECT. Subsequently, the patients received 10 mg NICORANDIL BD (20 mg per day). After starting NICORANDIL for one month, patients underwent dipyridamole stress/rest gated 99mTc-sestamibi SPECT again. GATED SPECT images were analyzed based on 17-segment scoring system, and QPS (quantitative perfusion SPECT) and QGS (quantitative GATED SPECT) softwares were used.Results: In patients with SCF subtle perfusion abnormality was noticed. With NICORANDIL consumption, EDV and ESV were decreased and LVEF was increased in both stress and rest GATED SPECT phases (P>0.05). After NICORANDIL consumption, decreased in most semi-quantitative perfusion indices (Severity score; P=0.03, Extension score; P=0.06, RAW reversibility; P=0.002, severity reversibility; P=0.03 and Extension reversibility; P=0.001) except for RAW score were observed demonstrating significant difference with pre-nicorandil consumption quantities. In multi-vessels involvement with SCF, there was a trend to see more abnormality with more remarkable post-nicorandil change as compared to the patients with one vessel involvement.Conclusion: The main finding of this study was better myocardial coronary flow after NICORANDIL consumption in patients with SCF specially those with multi-vessel involvement.

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APA: Copy

DABBAGH KAKHKI, VAHID REZA, ESHRAGHI, ALI, AYATI, NARJESS, VOJDANPARAST, MOHAMMAD, SADEGHI, RAMIN, & REZVANI KHORASHAD, AZADEH. (2017). NICORANDIL EFFECT ON MYOCARDIAL PERFUSION IN PATIENTS WITH SLOW CORONARY FLOW PHENOMENON ASSESSMENT BY GATED MYOCARDIAL PERFUSION SPECT. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 25(1 (SERIAL NUMBER 47)), 60-65. SID. https://sid.ir/paper/709169/en

Vancouver: Copy

DABBAGH KAKHKI VAHID REZA, ESHRAGHI ALI, AYATI NARJESS, VOJDANPARAST MOHAMMAD, SADEGHI RAMIN, REZVANI KHORASHAD AZADEH. NICORANDIL EFFECT ON MYOCARDIAL PERFUSION IN PATIENTS WITH SLOW CORONARY FLOW PHENOMENON ASSESSMENT BY GATED MYOCARDIAL PERFUSION SPECT. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2017;25(1 (SERIAL NUMBER 47)):60-65. Available from: https://sid.ir/paper/709169/en

IEEE: Copy

VAHID REZA DABBAGH KAKHKI, ALI ESHRAGHI, NARJESS AYATI, MOHAMMAD VOJDANPARAST, RAMIN SADEGHI, and AZADEH REZVANI KHORASHAD, “NICORANDIL EFFECT ON MYOCARDIAL PERFUSION IN PATIENTS WITH SLOW CORONARY FLOW PHENOMENON ASSESSMENT BY GATED MYOCARDIAL PERFUSION SPECT,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 1 (SERIAL NUMBER 47), pp. 60–65, 2017, [Online]. Available: https://sid.ir/paper/709169/en

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