Research Paper: GONAL-F Induced Endometrial ThicknessChanges in Ovariectomized Rats With and Without HCG

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YOUSEFI BEHPOOR; DADSERESHT SONIA; KARIMI MARYAM; Esmaeili Jalal

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Journal: Anatomical Sciences Journal Year:2017 | Volume:14 | Issue:3 Page(s): 133-140

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Title

Research Paper: GONAL-F Induced Endometrial ThicknessChanges in Ovariectomized Rats With and Without HCG

Author(s)

YOUSEFI BEHPOOR | DADSERESHT SONIA | KARIMI MARYAM | Esmaeili Jalal | Issue Writer Certificate

Keywords

Gonal-F

HCG

Endometrium

FSH

Implantation

Abstract

Introduction: To attach the fetus to the endometrial epithelium, the Endometrium should beaffected and allowed by the steroid hormones secreted from the ovary. Thus, the Endometriumis then subject to several structural and biochemical changes. Implantation involves theembedment, adhesion and invasion steps that specific receptors are engaged in that. Therole of membrane receptors in uterine epithelium is important. Most of these receptors areglycoprotein and among which integrins are of importance. In menstrual period, the uterusundergoes structural changes, so that Endometrium is provided for the placenta and the embryoin addition to extracellular matrix, especially fibronectin. Methods: The animals were anesthetized with ketamine and xylacin intraperitoneally, toperform surgery. After opening the abdomen, the ovaries were removed from both sides. After 72 hours, and observing the vaginal plaque, animals received high doses of ketamineand xylazine. The left uterine horn was removed and placed in fixative solutions and preparedfor cutting during the tissue processing of the molds. The slices were stained with PAS todetermine the glycoprotein layer thickness. Results: There is a statistically significant difference in the increased luminal membranethickness of glycoprotein layer of endometrial epithelium cells between the Gonal-F receptorgroups with HCG, compared to other groups at the same time. Conclusion: The study results indicated that Gonal-F and HCG can increase the amount ofglycoprotein expression without damaging the endometrial wall.

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APA: Copy

YOUSEFI, BEHPOOR, DADSERESHT, SONIA, KARIMI, MARYAM, & Esmaeili, Jalal. (2017). Research Paper: GONAL-F Induced Endometrial ThicknessChanges in Ovariectomized Rats With and Without HCG. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 14(3), 133-140. SID. https://sid.ir/paper/709468/en

Vancouver: Copy

YOUSEFI BEHPOOR, DADSERESHT SONIA, KARIMI MARYAM, Esmaeili Jalal. Research Paper: GONAL-F Induced Endometrial ThicknessChanges in Ovariectomized Rats With and Without HCG. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2017;14(3):133-140. Available from: https://sid.ir/paper/709468/en

IEEE: Copy

BEHPOOR YOUSEFI, SONIA DADSERESHT, MARYAM KARIMI, and Jalal Esmaeili, “Research Paper: GONAL-F Induced Endometrial ThicknessChanges in Ovariectomized Rats With and Without HCG,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 14, no. 3, pp. 133–140, 2017, [Online]. Available: https://sid.ir/paper/709468/en

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