THE ROLE OF T LYMPHOCYTE SUBSETS IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS

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ETESAM Z.; NEMATI M.; JAFARZADEH ABD ELAH

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Journal Paper

Paper Information

Journal: Journal of Rafsanjan University of Medical Sciences Year:2016 | Volume:15 | Issue:3 Page(s): 257-280

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Information Journal Paper

Title

THE ROLE OF T LYMPHOCYTE SUBSETS IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS

Author(s)

ETESAM Z. | NEMATI M. | JAFARZADEH ABD ELAH | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSISQ2

TH1Q1

TH2Q1

TH9Q1

TH17Q2

TH22Q2

TREGQ2

Abstract

Background and Objectives: MULTIPLE SCLEROSIS (MS) is an autoimmune neurodegenerative disease of the central nervous system (CNS). Although, the contribution of various cells such as B cells, CD8+T cells, microglia/macrophages, dendritic cells, asterocytes and mast cells in the pathogenesis of MS have been demonstrated, however, it seems that autoreactive myelin specific CD4+T cells play a central role in pathological events contributing in MS pathogenesis. The aim was to evaluate the recent findings regarding the properties of T lymphocyte subsets and their roles in pathogenesis of MS disease. Functionally, distinct effector T cells are induced from naïve T cells upon antigenic stimulation, including TH1, TH2, TH17, TH22, TH9, and regulatory T (Treg) cells which are characterized based on their cytokine patterns. Of the activated T cells, TH1 cells secreting IFN-g, TH17 cells producing IL-17, TH9 releasing IL-9, and TH22 secreting IL-22 play major roles in MS development, while TH2 cells producing IL-4, and TREG cells secreting IL-10 and TGF-ᵦ have been associated with a reduction of CNS inflammation and improvement of MS. The modulation of TH1, TH17, TH9 and TH22 cells activity and the promotion of TH2 and TREG cell-related responses can be more consider for immunological treatment of MS disease.

Cites

A REVIEW ON FINGOLIMOD; THE FIRST ORAL MEDICATION FOR MULTIPLE SCLEROSIS

References

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APA: Copy

ETESAM, Z., NEMATI, M., & JAFARZADEH, ABD ELAH. (2016). THE ROLE OF T LYMPHOCYTE SUBSETS IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 15(3), 257-280. SID. https://sid.ir/paper/71189/en

Vancouver: Copy

ETESAM Z., NEMATI M., JAFARZADEH ABD ELAH. THE ROLE OF T LYMPHOCYTE SUBSETS IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2016;15(3):257-280. Available from: https://sid.ir/paper/71189/en

IEEE: Copy

Z. ETESAM, M. NEMATI, and ABD ELAH JAFARZADEH, “THE ROLE OF T LYMPHOCYTE SUBSETS IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 15, no. 3, pp. 257–280, 2016, [Online]. Available: https://sid.ir/paper/71189/en

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