TRANS-CHALCONE ENHANCES INSULIN SENSITIVITY THROUGH THE MIR-34A/SIRT1 PATHWAY

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KARIMI SALES ELHAM; JEDDI SAJAD; EBRAHIMI KALAN ABBAS; ALIPOUR MOHAMMAD REZA

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:4 Page(s): 359-363

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Title

TRANS-CHALCONE ENHANCES INSULIN SENSITIVITY THROUGH THE MIR-34A/SIRT1 PATHWAY

Author(s)

KARIMI SALES ELHAM | JEDDI SAJAD | EBRAHIMI KALAN ABBAS | ALIPOUR MOHAMMAD REZA | Issue Writer Certificate

Keywords

MIR-34A

RAT

SIRT1

TRANS-CHALCONE

Abstract

Objective (s): TRANS-CHALCONE as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of MIR-34A controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of TRANS-CHALCONE on the MIR-34A/SIRT1 pathway as a possible mechanism for its hypoglycemic and hypoinsulinemic effects.Materials and Methods: In this study, thirty male RATs were randomly divided into three groups (n=10): solvent control (NS), oral administration of TRANS-CHALCONE for 2 (N2T) and 6 weeks (N6T) groups. Then, hepatic levels of MIR-34A and SIRT1 were measured through the qRT-PCR method.Results: TRANS-CHALCONE reduced food intake, body weight gain, and serum glucose as well as insulin levels.Also, this chalcone inhibited hepatic MIR-34A expression and significantly elevated SIRT1 mRNA level.Conclusion: TRANS-CHALCONE as an insulin-sensitizing chalcone partly acts through the MIR-34A/SIRT1 pathway.

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APA: Copy

KARIMI SALES, ELHAM, JEDDI, SAJAD, EBRAHIMI KALAN, ABBAS, & ALIPOUR, MOHAMMAD REZA. (2018). TRANS-CHALCONE ENHANCES INSULIN SENSITIVITY THROUGH THE MIR-34A/SIRT1 PATHWAY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(4), 359-363. SID. https://sid.ir/paper/712209/en

Vancouver: Copy

KARIMI SALES ELHAM, JEDDI SAJAD, EBRAHIMI KALAN ABBAS, ALIPOUR MOHAMMAD REZA. TRANS-CHALCONE ENHANCES INSULIN SENSITIVITY THROUGH THE MIR-34A/SIRT1 PATHWAY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(4):359-363. Available from: https://sid.ir/paper/712209/en

IEEE: Copy

ELHAM KARIMI SALES, SAJAD JEDDI, ABBAS EBRAHIMI KALAN, and MOHAMMAD REZA ALIPOUR, “TRANS-CHALCONE ENHANCES INSULIN SENSITIVITY THROUGH THE MIR-34A/SIRT1 PATHWAY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 4, pp. 359–363, 2018, [Online]. Available: https://sid.ir/paper/712209/en

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