IDENTIFICATION OF POTENTIAL MOLECULAR MECHANISMS AND CANDIDATE GENES INVOLVED IN THE ACUTE PHASE OF MYOCARDIAL INFARCTION

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YANG YUSHUANG; YANG JIE; SUI FENGHUA; HUO PENGFEI; YANG HAILING

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Journal: Cell Journal (Yakhteh) Year:2018 | Volume:20 | Issue:3 Page(s): 435-442

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Title

IDENTIFICATION OF POTENTIAL MOLECULAR MECHANISMS AND CANDIDATE GENES INVOLVED IN THE ACUTE PHASE OF MYOCARDIAL INFARCTION

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Keywords

GENE EXPRESSION PROFILE

MYOCARDIAL INFARCTION

PROTEIN-PROTEIN INTERACTION NETWORK

TRANSCRIPTIONAL REGULATORY NETWORK

Abstract

Objective: This study used bioinformatics to determine genetic factors involved in progression of acute MYOCARDIAL INFARCTION (MI).Materials and Methods: In this prospective study, GENE EXPRESSION PROFILE GSE59867 was downloaded from the Gene Expression Omnibus database, which contained 46 normal samples obtained from stable coronary artery disease patients (n=46) who were without history of MI (control) and 390 samples from patients (n=111) who had evolving ST-segment elevation MYOCARDIAL INFARCTION (STEMI) as the MI group. These samples were divided into 4 groups based on time points. After identification of differentially expressed genes (DEGs), we conducted hierarchical clustering and functional enrichment analysis. Protein interaction and transcriptional regulation among DEGs were analysed.Results: We observed 8 clusters of DEGs that had a peak or a minimum at the t=1 time point according to gene expression levels. Upregulated DEGs showed significant enrichment in the biological process, single-organism cellular process, response to stimulus and stress, and osteoclast differentiation and lysosome. Downregulated DEGs enriched in the T-cell receptor signalling pathway and natural killer cell mediated cytotoxicity. We identified multiple genes, including signal transducer and activator of transcription 3 (STAT3); LCK proto-oncogene, Src family tyrosine kinase (LCK); and FYN proto-oncogene, Src family tyrosine kinase (FYN) from the protein-protein interaction (PPI) network and/or the TRANSCRIPTIONAL REGULATORY NETWORK.Conclusion: Cytokine-mediated inflammation, lysosome and osteoclast differentiation, and metabolism processes, as well as STAT3 may be involved in the acute phase of MI.

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APA: Copy

YANG, YUSHUANG, YANG, JIE, SUI, FENGHUA, HUO, PENGFEI, & YANG, HAILING. (2018). IDENTIFICATION OF POTENTIAL MOLECULAR MECHANISMS AND CANDIDATE GENES INVOLVED IN THE ACUTE PHASE OF MYOCARDIAL INFARCTION. CELL JOURNAL (YAKHTEH), 20(3), 435-442. SID. https://sid.ir/paper/712231/en

Vancouver: Copy

YANG YUSHUANG, YANG JIE, SUI FENGHUA, HUO PENGFEI, YANG HAILING. IDENTIFICATION OF POTENTIAL MOLECULAR MECHANISMS AND CANDIDATE GENES INVOLVED IN THE ACUTE PHASE OF MYOCARDIAL INFARCTION. CELL JOURNAL (YAKHTEH)[Internet]. 2018;20(3):435-442. Available from: https://sid.ir/paper/712231/en

IEEE: Copy

YUSHUANG YANG, JIE YANG, FENGHUA SUI, PENGFEI HUO, and HAILING YANG, “IDENTIFICATION OF POTENTIAL MOLECULAR MECHANISMS AND CANDIDATE GENES INVOLVED IN THE ACUTE PHASE OF MYOCARDIAL INFARCTION,” CELL JOURNAL (YAKHTEH), vol. 20, no. 3, pp. 435–442, 2018, [Online]. Available: https://sid.ir/paper/712231/en

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