An Increase in Antimicrobial Effects of Standard Antibiotics in Combination with the Active Metabolites Isolated from Marine Streptomyces: A Laboratory Study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NOROUZI H.; RABBANI KHORASGANI M.; DANESH A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Rafsanjan University of Medical Sciences Year:2020 | Volume:18 | Issue:10 Page(s): 1017-1034

Download Full-Text

Persian Verion

View:

408

Download:

Cites:

Information Journal Paper

Title

An Increase in Antimicrobial Effects of Standard Antibiotics in Combination with the Active Metabolites Isolated from Marine Streptomyces: A Laboratory Study

Author(s)

NOROUZI H. | RABBANI KHORASGANI M. | DANESH A. | Issue Writer Certificate

Keywords

Marine StreptomycesQ1

Multidrug-resistant pathogensQ1

Antimicrobial effectsQ2

Abstract

Background and Objectives: Combination therapy has been considered as a potential approach to overcome antimicrobial resistance. In this study the Antimicrobial effects of active compounds produced by some Marine Streptomyces spp. in combination with some standard antibiotics against Multidrug-resistant pathogens was investigated. Materials and Methods: In this laboratory study, the bacteria isolated from Caspian Sea were tested for their ability to produce antimicrobial compounds active against some drug-resistant pathogens using disc diffusion methods. Then, the producer strains were cultivated in suitable liquid media. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the ethyl acetate extracts were measured against some drug-resistant species including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) using microbroth dilution technique. Data was analysed using paired t-test. Results: In the first screening, strains MN2, MN39, MN40 and MN41 showed a broad antimicrobial activity against MRSA, VRE, Salmonella typhi and pseudomonas aeruginosa, among which, the best MIC against MRSA was obtained from strain MN39 at 280 (μ g/ml). These extracts in combination with some standard antibiotics resulted in a noticeable improved antimicrobial activity against Multidrug-resistant pathogens, while in some cases the activity was decreased. Conclusion: The bioactive compounds produced by actinomyces possess remarkable antimicrobial properties against drug-resistant pathogens when used in a combination therapy with standard antibiotics which requires further research in the future.

Cites

No record.

References

Cite

APA: Copy

NOROUZI, H., RABBANI KHORASGANI, M., & DANESH, A.. (2020). An Increase in Antimicrobial Effects of Standard Antibiotics in Combination with the Active Metabolites Isolated from Marine Streptomyces: A Laboratory Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 18(10 ), 1017-1034. SID. https://sid.ir/paper/71273/en

Vancouver: Copy

NOROUZI H., RABBANI KHORASGANI M., DANESH A.. An Increase in Antimicrobial Effects of Standard Antibiotics in Combination with the Active Metabolites Isolated from Marine Streptomyces: A Laboratory Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2020;18(10 ):1017-1034. Available from: https://sid.ir/paper/71273/en

IEEE: Copy

H. NOROUZI, M. RABBANI KHORASGANI, and A. DANESH, “An Increase in Antimicrobial Effects of Standard Antibiotics in Combination with the Active Metabolites Isolated from Marine Streptomyces: A Laboratory Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 18, no. 10 , pp. 1017–1034, 2020, [Online]. Available: https://sid.ir/paper/71273/en

Related Journal Papers