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Information Journal Paper

Title

Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines

Pages

  601-607

Abstract

 Objective(s): Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties. In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines. This study assesses the effects of VPA on human papillomavirus E7 expression in HPV positive cell lines. Materials and Methods: Cell lines were treated by 2 mmol/l VPA and expression of E-cadherin and E7 was analyzed by quantitative real-time PCR. Student’ s t test and ANOVA were used to determine changes in expression levels. Results: The results revealed that mean of E-cadherin expression is increased by VPA 1. 8 times in HCT116 and MKN45 cell lines, also the mean of E-cadherin mRNA levels is up-regulated 2. 9 times in HeLa and TC1 cell lines. So, E-cadherin augmentation induced by VPA in HeLa and TC-1, HPV positive cell lines, is higher than HPV negative cell lines MKN45 and HCT116. The mean of HPV E7 expression is decreased by VPA, 4. 6 times in in HeLa and TC-1 cell lines. Conclusion: This study demonstrates that re-expression of E-cadherin by VPA in HPV positive cell lines is more than HPV negative cell lines. Whereas, HPV E7 reduces the expression of E-cadherin, reduction of HPV E7 expression by VPA is related to more augmentation of E-cadherin in HPV positive cell lines. So, this study demonstrates that VPA has more anticancer properties in HPV positive cell lines, and could potentially be a promising candidate for Cervical cancer treatment.

Cites

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    • Cite

    APA: Copy

    FAGHIHLOO, EBRAHIM, AKBARI, ABOLFAZL, ADJAMINEZHAD FARD, FATEMEH, & MOKHTARI AZAD, TALAT. (2016). Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(6), 601-607. SID. https://sid.ir/paper/713202/en

    Vancouver: Copy

    FAGHIHLOO EBRAHIM, AKBARI ABOLFAZL, ADJAMINEZHAD FARD FATEMEH, MOKHTARI AZAD TALAT. Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(6):601-607. Available from: https://sid.ir/paper/713202/en

    IEEE: Copy

    EBRAHIM FAGHIHLOO, ABOLFAZL AKBARI, FATEMEH ADJAMINEZHAD FARD, and TALAT MOKHTARI AZAD, “Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 6, pp. 601–607, 2016, [Online]. Available: https://sid.ir/paper/713202/en

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