THE ANGIOGENIC CHEMOKINES EXPRESSION PROFILE OF MYELOID CELL LINES CO-CULTURED WITH BONE MARROW-DERIVED MESENCHYMAL STEM CELLS

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MOHAMMADI NAJAFABADI MARYAM; SHAMSASENJAN KARIM; AKBARZADEHLALEH PARVIN

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Journal: Cell Journal (Yakhteh) Year:2018 | Volume:20 | Issue:1 Page(s): 19-24

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Title

THE ANGIOGENIC CHEMOKINES EXPRESSION PROFILE OF MYELOID CELL LINES CO-CULTURED WITH BONE MARROW-DERIVED MESENCHYMAL STEM CELLS

Author(s)

MOHAMMADI NAJAFABADI MARYAM | SHAMSASENJAN KARIM | AKBARZADEHLALEH PARVIN | Issue Writer Certificate

Keywords

ACUTE MYELOID LEUKEMIA

ANGIOGENESIS

CHEMOKINE

MESENCHYMAL STEM CELL

Abstract

Objective: ANGIOGENESIS, the process of formation of new blood vessels, is essential for development of solid tumors. At first, it was first assumed that ANGIOGENESIS is not implicated in the development of ACUTE MYELOID LEUKEMIA (AML) as a liquid tumor. One of the most important elements in bone marrow microenvironment is MESENCHYMAL STEM CELLs (MSCs). These cells possess an intrinsic tropism for sites of tumor in various types of cancers and have an impact on solid tumors growth by affecting the angiogenic process. But so far, our knowledge is limited about MSCs’ role in liquid tumors ANGIOGENESIS. By increasing our knowledge about the role of MSCs on ANGIOGENESIS, new therapeutic strategies can be used to improve the status of patients with leukemia.Materials and Methods: In this experimental study, HL-60, K562 and U937 cells were separately co-cultured with bone marrow derived-MSCs and after 8, 16 and 24 hours, alterations in the expression of 10 CHEMOKINE genes involved in ANGIOGENESIS, were evaluated by quantitative real time-polymerase chain reaction (qRT-PCR). Mono-cultures of leukemia cell lines were used as controls.Results: We observed that in HL-60 and K562 cells co-cultured with MSCs, the expression of CXCL10 and CXCL3 genes are increased, respectively as compared to the control cells. Also, in U937 cells co-cultured with MSCs, the expression ofCXCL6 gene was upgraded. Moreover in U937 cells, CCL2 gene expression in the first 16 hours was lower than the control cells, while within 24 hours its expression augmented.Conclusion: Our observations, for the first time, demonstrated that bone marrow (BM) -MSCs are able to alter the expression profile of CHEMOKINE genes involved in ANGIOGENESIS, in ACUTE MYELOID LEUKEMIA cell lines. MSCs cause different effects on ANGIOGENESIS in different leukemia cell lines; in some cases, MSCs promote ANGIOGENESIS, and in others, inhibit it.

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APA: Copy

MOHAMMADI NAJAFABADI, MARYAM, SHAMSASENJAN, KARIM, & AKBARZADEHLALEH, PARVIN. (2018). THE ANGIOGENIC CHEMOKINES EXPRESSION PROFILE OF MYELOID CELL LINES CO-CULTURED WITH BONE MARROW-DERIVED MESENCHYMAL STEM CELLS. CELL JOURNAL (YAKHTEH), 20(1), 19-24. SID. https://sid.ir/paper/713623/en

Vancouver: Copy

MOHAMMADI NAJAFABADI MARYAM, SHAMSASENJAN KARIM, AKBARZADEHLALEH PARVIN. THE ANGIOGENIC CHEMOKINES EXPRESSION PROFILE OF MYELOID CELL LINES CO-CULTURED WITH BONE MARROW-DERIVED MESENCHYMAL STEM CELLS. CELL JOURNAL (YAKHTEH)[Internet]. 2018;20(1):19-24. Available from: https://sid.ir/paper/713623/en

IEEE: Copy

MARYAM MOHAMMADI NAJAFABADI, KARIM SHAMSASENJAN, and PARVIN AKBARZADEHLALEH, “THE ANGIOGENIC CHEMOKINES EXPRESSION PROFILE OF MYELOID CELL LINES CO-CULTURED WITH BONE MARROW-DERIVED MESENCHYMAL STEM CELLS,” CELL JOURNAL (YAKHTEH), vol. 20, no. 1, pp. 19–24, 2018, [Online]. Available: https://sid.ir/paper/713623/en

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