THE INHIBITORY EFFECTS OF 20(R)-GINSENOSIDE RG3 ON THE PROLIFERATION, ANGIOGENESIS, AND COLLAGEN SYNTHESIS OF HYPERTROPHIC SCAR DERIVED FIBROBLASTS IN VITRO

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TANG MENGYAO; WANG WENBO; CHENG LIYING; JIN RONG; ZHANG LU; BIAN WEIWEI; ZHANG YUGUANG

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:3 Page(s): 309-317

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Title

THE INHIBITORY EFFECTS OF 20(R)-GINSENOSIDE RG3 ON THE PROLIFERATION, ANGIOGENESIS, AND COLLAGEN SYNTHESIS OF HYPERTROPHIC SCAR DERIVED FIBROBLASTS IN VITRO

Author(s)

Keywords

FIBROBLAST

GINSENOSIDE RG (3)

HYPERTROPHIC SCAR

SIGNAL TRANSDUCTION

WOUND HEALING

Abstract

Objective (s): Therapeutic effect of many selectable methods applied in clinical practice for treating HYPERTROPHIC SCAR (HS) is not still so satisfactory. Meanwhile, a few medicines may lead to several undesirable complications. The traditional Chinese medicine, Rg3, has been reported for multiple antitumor effects previously. We have conducted series of animal experiments and confirmed the inhibitory effect of Rg3 in HS before. The aim of this study was to further verify the conclusions of previous studies and reveal the specific functional mechanisms of Rg3.Materials and Methods: The HS specimens were obtained from the patients aged from 15 to 36 years without systemic diseases and the primary cultured cells were isolated from the scar tissue and expanded in vitro. In every experiment, HYPERTROPHIC SCAR FIBROBLASTs (HSFs) were divided into three groups and respectively cultured in medium with or without different Rg3 concentrations (50, 100 mg/ml). Cell viability assay, flow cytometry analysis (FCM), quantitative PCR, cell migration assay, immunofluorescence staining, western blot and ELISA were employed.Results: The outcomes demonstrated that Rg3 could suppress cell proliferation, vascularization and extracellular matrix (ECM) deposition of HSFs in vitro by TGF-b /SMAD and Erk signaling pathways. Significant statistical differences were between control group and Rg3-treated groups (P<0.05).Conclusion: This study provides sufficient in vitro evidences for Rg3 as a promising drug in the treatment of human HS.

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APA: Copy

TANG, MENGYAO, WANG, WENBO, CHENG, LIYING, JIN, RONG, ZHANG, LU, BIAN, WEIWEI, & ZHANG, YUGUANG. (2018). THE INHIBITORY EFFECTS OF 20(R)-GINSENOSIDE RG3 ON THE PROLIFERATION, ANGIOGENESIS, AND COLLAGEN SYNTHESIS OF HYPERTROPHIC SCAR DERIVED FIBROBLASTS IN VITRO. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(3), 309-317. SID. https://sid.ir/paper/714172/en

Vancouver: Copy

TANG MENGYAO, WANG WENBO, CHENG LIYING, JIN RONG, ZHANG LU, BIAN WEIWEI, ZHANG YUGUANG. THE INHIBITORY EFFECTS OF 20(R)-GINSENOSIDE RG3 ON THE PROLIFERATION, ANGIOGENESIS, AND COLLAGEN SYNTHESIS OF HYPERTROPHIC SCAR DERIVED FIBROBLASTS IN VITRO. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(3):309-317. Available from: https://sid.ir/paper/714172/en

IEEE: Copy

MENGYAO TANG, WENBO WANG, LIYING CHENG, RONG JIN, LU ZHANG, WEIWEI BIAN, and YUGUANG ZHANG, “THE INHIBITORY EFFECTS OF 20(R)-GINSENOSIDE RG3 ON THE PROLIFERATION, ANGIOGENESIS, AND COLLAGEN SYNTHESIS OF HYPERTROPHIC SCAR DERIVED FIBROBLASTS IN VITRO,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 3, pp. 309–317, 2018, [Online]. Available: https://sid.ir/paper/714172/en

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