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Information Journal Paper

Title

BAX/BCL-2 EXPRESSION RATIO IN PREDICTION OF RESPONSE TO BREAST CANCER RADIOTHERAPY

Author(s)

 AZIMIAN HOSEIN | DAYYANI MAHDIEH | BAHREYNI TOOSSI MOHAMMAD TAGHI | MAHMOUDI MAHMOUD | Issue Writer Certificate 

Pages

  325-332

Abstract

 Objective (s): RADIOTHERAPY is one of the most effective modalities of cancer therapy, but clinical responses of individual patients varies considerably. To enhance treatment efficiency it is essential to implement an individual-based treatment. The aim of present study was to identify the mechanism of intrinsic apoptosis pathway on radio sensitivity and normal tissue complications caused by the RADIOTHERAPY.Materials and Methods: Peripheral blood mononuclear cells from ten BREAST CANCER patients were exposed to 6MV X-rays to deliver 1 and 2 Gy. Expression levels of BAX, BCL-2, and BAX/Bcl-2 ratio were examined by relative quantitative RT-PCR. All the patients received similar tangential irradiation of the whole breast and conventional fractionation. Skin dosimetry was done by GAF Chromic EBT-3 film and clinical radio sensitivity was determined using the acute reactions to RADIOTHERAPY of the skin according to Radiation Therapy Oncology Group score. All statistical analyses were performed using Graph Pad Prism, version 7.01.Results: In the in-vitro experiment, BAX and BAX/Bcl-2 ratios were significantly increased with 1 and 2 Gy doses (P<0.001 and P<0.0001, respectively). Herein, the notable result was a significant correlation between dose-response curve slope (as an in-vitro radio sensitivity index) and acute skin toxicity score following irradiation (as a clinical radio sensitivity index). There was no significant relationship between skin dose and reactions (P>0.05 for all patients).Conclusion: Significant correlation between BAX/Bcl-2 ratio determined before radiation therapy and clinical response in the patients, can be used as a biomarker to identify radiosensitive individuals. However, further studies are required to validate radiation-induced apoptotic biomarkers.

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    APA: Copy

    AZIMIAN, HOSEIN, DAYYANI, MAHDIEH, BAHREYNI TOOSSI, MOHAMMAD TAGHI, & MAHMOUDI, MAHMOUD. (2018). BAX/BCL-2 EXPRESSION RATIO IN PREDICTION OF RESPONSE TO BREAST CANCER RADIOTHERAPY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(3), 325-332. SID. https://sid.ir/paper/714173/en

    Vancouver: Copy

    AZIMIAN HOSEIN, DAYYANI MAHDIEH, BAHREYNI TOOSSI MOHAMMAD TAGHI, MAHMOUDI MAHMOUD. BAX/BCL-2 EXPRESSION RATIO IN PREDICTION OF RESPONSE TO BREAST CANCER RADIOTHERAPY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(3):325-332. Available from: https://sid.ir/paper/714173/en

    IEEE: Copy

    HOSEIN AZIMIAN, MAHDIEH DAYYANI, MOHAMMAD TAGHI BAHREYNI TOOSSI, and MAHMOUD MAHMOUDI, “BAX/BCL-2 EXPRESSION RATIO IN PREDICTION OF RESPONSE TO BREAST CANCER RADIOTHERAPY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 3, pp. 325–332, 2018, [Online]. Available: https://sid.ir/paper/714173/en

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