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Information Journal Paper

Title

PROTECTIVE EFFECT OF ALOE VERA EXTRACT AGAINST BISPHENOL A INDUCED TESTICULAR TOXICITY IN WISTAR RATS

Pages

  278-283

Abstract

 Objective: BISPHENOL A (BPA), an endocrine-disrupting chemical, has been considered as a possible risk factor for fertility because it induces testicular toxicity. Thus, we sought to analyze the effect of ALOE VERA as plant with antioxidant properties on tissues and oxidative stress parameters in male RATs.Materials and Methods: In this experimental study, 50 adult male Wistar RATs (200 ± 20 g) have been used in this 56 day study. Animals were completely randomized and divided into five groups: A1 (control), A2 (vehicle control), A3 (ALOE VERA gel 300 mg/kg), B1 (BPA 20 mg/kg bw) and B2 (ALOE VERA gel+ BPA). At the end of the study, the RATs were anesthetized and 2 ml blood samples were obtained for evaluation of oxidative stress markers. Also, both testes were collected for histological examinations.Results: BPA significantly decreased (P<0.05) body and TESTIS weights. Seminiferous tubule diameter (STD) and height of seminiferous epithelium (HSE), were significantly decreased (P<0.05) in the groups receiving BPA as compared to the control. There was also a reduction in the quantity of spermatocyte and spermatids. Moreover, malondialdehyde (MDA) increased and thiol protein (G-SH) decreased. But, co-administration of ALOE VERA with BPA accelerated the total antioxidant capacity and testicular tissue structure healing.Conclusion: According to our findings, ALOE VERA gel extract can overcome the damaging effects of BPA on the reproductive system of RATs and protects RATs’ testes against BPA-induced toxicity.

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    Cite

    APA: Copy

    BEHMANESH, MOHAMMAD AMIN, NAJAFZADEH VARZI, HOSEIN, & POURMOUSAVI, SEYEDEH MAHSA. (2018). PROTECTIVE EFFECT OF ALOE VERA EXTRACT AGAINST BISPHENOL A INDUCED TESTICULAR TOXICITY IN WISTAR RATS. CELL JOURNAL (YAKHTEH), 20(2), 278-283. SID. https://sid.ir/paper/714994/en

    Vancouver: Copy

    BEHMANESH MOHAMMAD AMIN, NAJAFZADEH VARZI HOSEIN, POURMOUSAVI SEYEDEH MAHSA. PROTECTIVE EFFECT OF ALOE VERA EXTRACT AGAINST BISPHENOL A INDUCED TESTICULAR TOXICITY IN WISTAR RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2018;20(2):278-283. Available from: https://sid.ir/paper/714994/en

    IEEE: Copy

    MOHAMMAD AMIN BEHMANESH, HOSEIN NAJAFZADEH VARZI, and SEYEDEH MAHSA POURMOUSAVI, “PROTECTIVE EFFECT OF ALOE VERA EXTRACT AGAINST BISPHENOL A INDUCED TESTICULAR TOXICITY IN WISTAR RATS,” CELL JOURNAL (YAKHTEH), vol. 20, no. 2, pp. 278–283, 2018, [Online]. Available: https://sid.ir/paper/714994/en

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