ENDOPLASMIC RETICULUM STRESS REGULATES INFLAMMATION IN ADIPOCYTE OF OBESE RATS VIA TOLL-LIKE RECEPTORS 4 SIGNALING

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LI XIAOHUA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:5 Page(s): 502-507

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Title

ENDOPLASMIC RETICULUM STRESS REGULATES INFLAMMATION IN ADIPOCYTE OF OBESE RATS VIA TOLL-LIKE RECEPTORS 4 SIGNALING

Author(s)

LI XIAOHUA | Issue Writer Certificate

Keywords

ADIPOCYTE

ENDOPLASMIC RETICULUM STRESS

INFLAMMATION

OBESITY

TOLL-LIKE RECEPTOR 4

Abstract

Objective (s): To explore whether endoplasmic reticulum (ER) stress regulates INFLAMMATION in adipose tissue of obese rats via TLR4 signaling.Materials and Methods: Sprague Dawley rats were randomly divided into four groups, and body weight, food intake, and free fatty acids (FFA) were measured. Real-time PCR and Western blot were used to determine mRNA or protein expression of TLR4, TRAF6, IKKb, TNF-a, IL-6, and GRP78. Immunohistochemistry was used to detect GRP78 protein expression.Results: The FFA levels in HFD, HFD+PBA, and HFD+VIPER groups were higher than that in the control group (P<0.05). Compared with the control group, HFD induced GRP78 expression significantly (P<0.05), which could be decreased by ER stress inhibitor but not by TLR4 blocker. The mRNA expression of TLR4, TRAF6, TNF-a, and IL-6, and protein levels of TLR4, TNF-a, and IKKb in the HFD group increased significantly compared with the control group (P<0.05), while these changes could be suppressed by PBA or VIPER (P<0.05). The immunohistochemistry staining indicated GRP78 expression in the HFD group was higher than that of the control group, which could be inhibited by PBA or VIPER.Conclusion: HFD could induce INFLAMMATION in adipose tissue via ER stress and its downstream TLR4 signaling.

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APA: Copy

LI, XIAOHUA. (2018). ENDOPLASMIC RETICULUM STRESS REGULATES INFLAMMATION IN ADIPOCYTE OF OBESE RATS VIA TOLL-LIKE RECEPTORS 4 SIGNALING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(5), 502-507. SID. https://sid.ir/paper/715007/en

Vancouver: Copy

LI XIAOHUA. ENDOPLASMIC RETICULUM STRESS REGULATES INFLAMMATION IN ADIPOCYTE OF OBESE RATS VIA TOLL-LIKE RECEPTORS 4 SIGNALING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(5):502-507. Available from: https://sid.ir/paper/715007/en

IEEE: Copy

XIAOHUA LI, “ENDOPLASMIC RETICULUM STRESS REGULATES INFLAMMATION IN ADIPOCYTE OF OBESE RATS VIA TOLL-LIKE RECEPTORS 4 SIGNALING,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 5, pp. 502–507, 2018, [Online]. Available: https://sid.ir/paper/715007/en

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