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Information Journal Paper

Title

THE EFFICACY OF CEREBROLYSIN IN IMPROVEMENT OF SPASTICITY IN CHILDREN WITH CEREBRAL PALSY: A CLINICAL TRIAL

Pages

  1-6

Abstract

 Background: CEREBRAL PALSY (CP) constitutes a heterogeneous group of developmental disorders resulting from damage to the brain which affects motor system. CEREBROLYSIN, as a neurotrophic peptide has been used for improving symptoms of patients suffering from neurodegenerative disorders.Objectives: Due to the presence of limited information about the usefulness of CEREBROLYSIN in CP, this study was performed for the evaluation of CEREBROLYSIN in the management of SPASTICITY in children with CP.Methods: 26 Spastic CP patients aged between 2 and 6 years entered this study. At the first visit, Modified Ashworth scale for assessment of SPASTICITY was used. Then CEREBROLYSIN was administered at a dose of 0.1 cc/kg intramuscularly (IM) for 3 months. In the first month, the medication was injected 5 times per week. In the second month of therapy, injections were performed as follows: 4 injections in the first week, 3 injections in the second week, 2 injections in the third week and a single one in the fourth week. In the third month of therapy, CEREBROLYSIN was continued as weekly injections. The SPASTICITY of the patients was evaluated at the end of the first and third month of therapy.Results: Modified Ashworth score at baseline was 20.629.65 which reached 15.197.30 after 1monthof treatment. This figure was 14.813.77 at month 3. Total decline in Modified Ashworth Scale was 5.425.33 at the first month and 5.812.74 at the third month in comparison to baseline. The difference between Modified Ashworth Scale at baseline and 1 month after therapy was significant (P =0.000) but there was no significant difference between first month and third month of therapy. (P=0.755). Also analysis indicates that there was an association between absolute reduction of Modified Ashworth score and the age at beginning of treatment (P= 0.037).Conclusions: Using CEREBROLYSIN as a neurotrophic peptide may improve SPASTICITY of children with CP and should be considered as a possible useful treatment in CP cases.

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    APA: Copy

    ASHRAFI, MAHMOUD REZA, SHAHROKHI, AMIN, TAVASOLI, ALI REZA, HOSSEINI, SEYED AHMAD, HEIDARI, MORTEZA, SALEHI, MONA, FATTAH DIZAJI, ELNAZ, & AMANAT, MAN. (). . , (), -. SID. https://sid.ir/paper/715266/en

    Vancouver: Copy

    ASHRAFI MAHMOUD REZA, SHAHROKHI AMIN, TAVASOLI ALI REZA, HOSSEINI SEYED AHMAD, HEIDARI MORTEZA, SALEHI MONA, FATTAH DIZAJI ELNAZ, AMANAT MAN. . [Internet]. ;():-. Available from: https://sid.ir/paper/715266/en

    IEEE: Copy

    MAHMOUD REZA ASHRAFI, AMIN SHAHROKHI, ALI REZA TAVASOLI, SEYED AHMAD HOSSEINI, MORTEZA HEIDARI, MONA SALEHI, ELNAZ FATTAH DIZAJI, and MAN AMANAT, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/715266/en

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