5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION

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HU BING; FENG XIAOQIAN; WANG LI; SONG YINLI; NI XIUQIN

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:4 Page(s): 364-369

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Title

5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION

Author(s)

Keywords

5-BDBD

ASTHMA

GATA-3

T-BET

TH2 CELLS

Abstract

Objective (s): P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice.Materials and Methods: Ovalbumin was used to sensitize and challenge for a mouse model. Intranasal application of 5-BDBD, P2X4R antagonist, were performed 3 hr before each airway allergen challenge.The lung was evaluated for P2X4R by real-time PCR and immunofluorescence. Th1/Th2 cytokines in bronchoalveolar lavage fluid were measured by ELISA. T-BET, GATA-3, and p-p38 MAPK were measured by Western blot or real-time PCR.Results: P2X4R was overexpressed in the lung after allergen challenge compared with the control group. Blockage of P2X4R decreased inflammation in the lung, IL-4 expression was reduced as well as IL-5; IFN-g expression was elevated in BALF in ovalbumin-sensitized mice. Moreover, blockage of P2X4R inhibited ovalbumin-induced increased GATA-3 level and decreased T-BET level.Conclusion: These findings suggest that 5-BDBD ameliorates an ovalbumin-induced ASTHMAtic attack by the downregulation of cytokines related to the Th2 cell.

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APA: Copy

HU, BING, FENG, XIAOQIAN, WANG, LI, SONG, YINLI, & NI, XIUQIN. (2018). 5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(4), 364-369. SID. https://sid.ir/paper/715419/en

Vancouver: Copy

HU BING, FENG XIAOQIAN, WANG LI, SONG YINLI, NI XIUQIN. 5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(4):364-369. Available from: https://sid.ir/paper/715419/en

IEEE: Copy

BING HU, XIAOQIAN FENG, LI WANG, YINLI SONG, and XIUQIN NI, “5-BDBD AMELIORATES AN OVA-INDUCED ALLERGIC ASTHMA BY THE REDUCTION OF TH2 CYTOKINES PRODUCTION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 4, pp. 364–369, 2018, [Online]. Available: https://sid.ir/paper/715419/en

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