SHOULD SUBCLINICAL HYPOTHYROIDISM BE AN EXCLUSION CRITERION FOR THE DIAGNOSIS OF POLYCYSTIC OVARY SYNDROME?

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DE MEDEIROS SEBASTIAO FREITAS; WINCK YAMAMOTO MARCIA MARLY; DE MEDEIROS MATHEUS ANTONIO SOUTO; BARBOSA JACKLYNE SILVA; NORMAN ROBERT JOHN

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Journal: Journal of Reproduction & Infertility Year:2017 | Volume:18 | Issue:2 Page(s): 242-250

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Title

SHOULD SUBCLINICAL HYPOTHYROIDISM BE AN EXCLUSION CRITERION FOR THE DIAGNOSIS OF POLYCYSTIC OVARY SYNDROME?

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Keywords

HYPERANDROGENISM

HYPOTHYROIDISM

POLYCYSTIC OVARY SYNDROME

THYROID HORMONES

Abstract

Background: The purpose of the study was to examine whether patients with subclinical HYPOTHYROIDISM (SCH) should be excluded before making a diagnosis of POLYCYSTIC OVARY SYNDROME (PCOS).Methods: Seven hundred sixteen patients, 462 with true PCOS, 31 with PCOS-SCH, and 223 normal cycling women were enrolled. Clinical, metabolic, and hormonal parameters among the groups were investigated. Continuous variables were compared by one-way analysis of variance. Proportions were compared using Z test. Fisher test was used to compare categorical variables. Simple correlation was performed using Spearman’s coefficient. Correlation between thyroid stimulating hormone (TSH) and dependent variables were performed using backward multiple regression. The significance level was set at 0.05.Results: True polycystic ovary and polycystic ovary with subclinical HYPOTHYROIDISM patients presented similar anthropometrical parameters. C-peptide was higher in polycystic ovary patients than in the other groups (p=0.014). Prevalence of glucose intolerance (p=0.186) and insulin resistance (p=0.293) was not statistically different in polycystic ovary and polycystic ovary with subclinical HYPOTHYROIDISM. TSH levels showed positive correlation with lean body mass (p=0.032), total cholesterol (p=0.046, insulin (p=0.048) and prolactin (p=0.047). Backward multiple regression model retained TC, insulin, and PRL as predictors of TSH levels (p=0.011).Conclusion: Anthropometric parameters and ovary morphology were similar in both PCOS and PCOS-with-SCH patients. Regarding hormones, only C-peptide was higher in PCOS group. TSH correlated with total cholesterol, insulin, and prolactin. Before PCOS diagnosis, the exclusion criterion thyroid dysfunction should be standardized and subclinical HYPOTHYROIDISM should not exclude a diagnosis of PCOS.

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APA: Copy

DE MEDEIROS, SEBASTIAO FREITAS, WINCK YAMAMOTO, MARCIA MARLY, DE MEDEIROS, MATHEUS ANTONIO SOUTO, BARBOSA, JACKLYNE SILVA, & NORMAN, ROBERT JOHN. (2017). SHOULD SUBCLINICAL HYPOTHYROIDISM BE AN EXCLUSION CRITERION FOR THE DIAGNOSIS OF POLYCYSTIC OVARY SYNDROME?. JOURNAL OF REPRODUCTION AND INFERTILITY, 18(2), 242-250. SID. https://sid.ir/paper/715459/en

Vancouver: Copy

DE MEDEIROS SEBASTIAO FREITAS, WINCK YAMAMOTO MARCIA MARLY, DE MEDEIROS MATHEUS ANTONIO SOUTO, BARBOSA JACKLYNE SILVA, NORMAN ROBERT JOHN. SHOULD SUBCLINICAL HYPOTHYROIDISM BE AN EXCLUSION CRITERION FOR THE DIAGNOSIS OF POLYCYSTIC OVARY SYNDROME?. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2017;18(2):242-250. Available from: https://sid.ir/paper/715459/en

IEEE: Copy

SEBASTIAO FREITAS DE MEDEIROS, MARCIA MARLY WINCK YAMAMOTO, MATHEUS ANTONIO SOUTO DE MEDEIROS, JACKLYNE SILVA BARBOSA, and ROBERT JOHN NORMAN, “SHOULD SUBCLINICAL HYPOTHYROIDISM BE AN EXCLUSION CRITERION FOR THE DIAGNOSIS OF POLYCYSTIC OVARY SYNDROME?,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 18, no. 2, pp. 242–250, 2017, [Online]. Available: https://sid.ir/paper/715459/en

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